CHISP_0268 protein (Chitinispirillum alkaliphilum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

CHISP_0268

UDP-N-acetylmuramoylalanine--D-glutamate ligase. (465 aa)

Predicted Functional Partners:

CHISP_0266

0.997

CHISP_0267

0.997

CHISP_0271

0.996

CHISP_0270

0.991

CHISP_2246

0.983

CHISP_2023

0.978

CHISP_0269

0.973

CHISP_2325

0.972

CHISP_0650

0.971

CHISP_2226

0.965

Your Current Organism:

Chitinispirillum alkaliphilum

NCBI taxonomy Id: 1008392
Other names: C. alkaliphilum, Chitinispirillum alkaliphilum Sorokin et al. 2016, DSM 24539, UNIQEM U893, haloalkaliphilic bacterium ACht6-1, strain ACht6-1

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CHISP_0266	CHISP_0267	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	0.999
CHISP_0266	CHISP_0268	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylmuramoylalanine--D-glutamate ligase.	0.997
CHISP_0266	CHISP_0269	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	Cell division protein FtsW.	0.900
CHISP_0266	CHISP_0270	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase.	0.979
CHISP_0266	CHISP_0271	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylmuramate--alanine ligase.	0.988
CHISP_0266	CHISP_0650	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	D-alanine--D-alanine ligase.	0.949
CHISP_0266	CHISP_2023	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	Phospho-N-acetylmuramoyl-pentapeptide- transferase.	0.961
CHISP_0266	CHISP_2226	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylenolpyruvoylglucosamine reductase.	0.762
CHISP_0266	CHISP_2246	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylmuramate--alanine ligase.	0.942
CHISP_0266	CHISP_2325	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase.	0.886
CHISP_0267	CHISP_0266	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase.	0.999
CHISP_0267	CHISP_0268	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylmuramoylalanine--D-glutamate ligase.	0.997
CHISP_0267	CHISP_0269	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	Cell division protein FtsW.	0.953
CHISP_0267	CHISP_0270	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase.	0.990
CHISP_0267	CHISP_0271	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylmuramate--alanine ligase.	0.984
CHISP_0267	CHISP_0650	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	D-alanine--D-alanine ligase.	0.992
CHISP_0267	CHISP_2023	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	Phospho-N-acetylmuramoyl-pentapeptide- transferase.	0.981
CHISP_0267	CHISP_2226	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylenolpyruvoylglucosamine reductase.	0.927
CHISP_0267	CHISP_2246	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylmuramate--alanine ligase.	0.965
CHISP_0267	CHISP_2325	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase.	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase.	0.976

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Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.873

expected number of edges:

14

PPI enrichment p-value:

1.12e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

9 of 230

1.0

1.06

1.01e-05

GO:0006810

Transport

10 of 347

0.87

0.86

1.01e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904680

Peptide transmembrane transporter activity

5 of 15

1.93

2.55

2.82e-06

GO:0022857

Transmembrane transporter activity

9 of 248

0.97

1.04

3.55e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

5 of 31

1.61

2.1

4.15e-06

GO:0030288

Outer membrane-bounded periplasmic space

5 of 51

1.4

1.68

1.02e-05

GO:0005886

Plasma membrane

11 of 405

0.84

0.91

7.20e-08

GO:0016021

Integral component of membrane

10 of 508

0.7

0.66

5.24e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3827

Solute-binding protein family 5, and Oligopeptide/dipeptide ABC transporter, C-terminal

10 of 23

2.05

6.11

6.46e-17

CL:3832

Peptide/nickel binding protein, MppA-type, and Oligopeptide/dipeptide ABC transporter, C-terminal

9 of 18

2.11

5.99

1.53e-15

CL:3836

Peptide/nickel binding protein, MppA-type, and Oligopeptide/dipeptide ABC transporter, C-terminal

6 of 11

2.14

4.22

6.37e-10

CL:3838

Oligopeptide/dipeptide ABC transporter, C-terminal, and Peptide/nickel binding protein, MppA-type

4 of 5

2.31

3.04

1.08e-06

CL:3848

Peptide/nickel binding protein, MppA-type, and Oligopeptide/dipeptide transporter, C-terminal region

2 of 5

2.01

0.93

0.0176

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02024

Quorum sensing

9 of 101

1.36

2.19

8.73e-10

map01501

beta-Lactam resistance

6 of 50

1.49

2.03

1.12e-06

map02010

ABC transporters

7 of 167

1.03

1.06

3.02e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

5 of 52

1.39

1.59

2.62e-05

MAP-9635486

Infection with Mycobacterium tuberculosis

5 of 85

1.18

1.17

0.00013

MAP-5663205

Infectious disease

5 of 94

1.13

1.11

0.00014

MAP-1643685

Disease

5 of 95

1.13

1.11

0.00014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030288

Outer membrane-bounded periplasmic space

4 of 20

1.71

1.59

0.00032

GOCC:0042597

Periplasmic space

5 of 96

1.12

0.88

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

5 of 105

1.08

0.78

0.0060

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00496

Bacterial extracellular solute-binding proteins, family 5 Middle

5 of 15

1.93

2.63

1.76e-06

PF00528

Binding-protein-dependent transport system inner membrane component

4 of 20

1.71

1.64

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039424

Solute-binding protein family 5

5 of 15

1.93

2.46

4.96e-06

IPR000914

Solute-binding protein family 5 domain

5 of 15

1.93

2.46

4.96e-06

IPR030678

Peptide/nickel binding protein, MppA-type

4 of 8

2.11

2.33

2.15e-05

IPR035906

MetI-like superfamily

4 of 20

1.71

1.58

0.00034

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

4 of 20

1.71

1.58

0.00034

(more ...)

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