CHISP_1447 protein (Chitinispirillum alkaliphilum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

CHISP_1447

Sensory box histidine kinase. (549 aa)

Predicted Functional Partners:

CHISP_2148

0.994

CHISP_0099

0.993

CHISP_0295

0.992

CHISP_1598

0.992

CHISP_0673

0.991

CHISP_0582

0.990

CHISP_0893

0.990

CHISP_1540

0.990

CHISP_0011

0.989

CHISP_3726

0.989

Your Current Organism:

Chitinispirillum alkaliphilum

NCBI taxonomy Id: 1008392
Other names: C. alkaliphilum, Chitinispirillum alkaliphilum Sorokin et al. 2016, DSM 24539, UNIQEM U893, haloalkaliphilic bacterium ACht6-1, strain ACht6-1

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CHISP_0011	CHISP_0099	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Sensor histidine kinase AtoS.	0.989
CHISP_0011	CHISP_0295	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	PAS/PAC sensor signal transduction histidine kinase.	0.984
CHISP_0011	CHISP_0582	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	PAS/PAC sensor protein.	0.979
CHISP_0011	CHISP_0673	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	PAS/PAC sensor hybrid histidine kinase.	0.981
CHISP_0011	CHISP_0893	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	PAS/PAC sensor hybrid histidine kinase.	0.981
CHISP_0011	CHISP_1447	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Sensory box histidine kinase.	0.989
CHISP_0011	CHISP_1540	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Signal transduction histidine kinase.	0.984
CHISP_0011	CHISP_1598	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Sensory box histidine kinase/response regulator.	0.985
CHISP_0011	CHISP_2148	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Multi-sensor hybrid histidine kinase.	0.991
CHISP_0011	CHISP_3726	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	LuxR family transcriptional regulator.	0.977
CHISP_0099	CHISP_0011	Sensor histidine kinase AtoS.	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	0.989
CHISP_0099	CHISP_0295	Sensor histidine kinase AtoS.	PAS/PAC sensor signal transduction histidine kinase.	0.991
CHISP_0099	CHISP_0582	Sensor histidine kinase AtoS.	PAS/PAC sensor protein.	0.985
CHISP_0099	CHISP_0673	Sensor histidine kinase AtoS.	PAS/PAC sensor hybrid histidine kinase.	0.984
CHISP_0099	CHISP_0893	Sensor histidine kinase AtoS.	PAS/PAC sensor hybrid histidine kinase.	0.991
CHISP_0099	CHISP_1447	Sensor histidine kinase AtoS.	Sensory box histidine kinase.	0.993
CHISP_0099	CHISP_1540	Sensor histidine kinase AtoS.	Signal transduction histidine kinase.	0.992
CHISP_0099	CHISP_1598	Sensor histidine kinase AtoS.	Sensory box histidine kinase/response regulator.	0.992
CHISP_0099	CHISP_2148	Sensor histidine kinase AtoS.	Multi-sensor hybrid histidine kinase.	0.997
CHISP_0099	CHISP_3726	Sensor histidine kinase AtoS.	LuxR family transcriptional regulator.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.945

expected number of edges:

13

PPI enrichment p-value:

0.000238

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005985

Sucrose metabolic process

3 of 3

2.23

1.38

0.0025

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 28

1.39

0.96

0.0060

GO:0005975

Carbohydrate metabolic process

6 of 138

0.87

0.63

0.0060

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004564

Beta-fructofuranosidase activity

3 of 3

2.23

1.65

0.00074

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

4 of 21

1.51

1.3

0.00088

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 36

1.38

1.22

0.00074

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

5 of 58

1.17

1.0

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1197

Mixed, incl. Glycosidase, and Amino sugar metabolic process

7 of 16

1.87

3.76

2.85e-10

CL:1196

Import across plasma membrane, and Glycosidase

9 of 31

1.7

3.64

3.74e-12

CL:1195

Mixed, incl. Phosphotransferase system (PTS), and Pentose phosphate pathway

10 of 60

1.46

2.76

3.84e-12

CL:1194

Mixed, incl. Phosphotransferase system (PTS), and Glycolysis / Gluconeogenesis

11 of 83

1.36

2.45

1.10e-12

CL:1218

Glycosidase, and Mannose-6-phosphate isomerase, type I

2 of 5

1.84

0.79

0.0308

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

6 of 69

1.17

0.00012

map02060

Phosphotransferase system (PTS)

4 of 30

1.36

1.14

0.0013

map00051

Fructose and mannose metabolism

3 of 21

1.39

0.89

0.0091

map00052

Galactose metabolism

3 of 25

1.31

0.83

0.0109

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 13

1.72

1.66

0.00022

KW-0598

Phosphotransferase system

3 of 12

1.63

1.09

0.0050

KW-0119

Carbohydrate metabolism

3 of 19

1.43

0.88

0.0111

KW-0762

Sugar transport

2 of 7

1.69

0.7

0.0426

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

2 of 2

2.23

0.71

0.0495

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023296

Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

3 of 3

2.23

1.39

0.0024

IPR013189

Glycosyl hydrolase family 32, C-terminal

3 of 3

2.23

1.39

0.0024

IPR013148

Glycosyl hydrolase family 32, N-terminal

3 of 3

2.23

1.39

0.0024

IPR006232

Sucrose-6-phosphate hydrolase

3 of 3

2.23

1.39

0.0024

IPR001362

Glycoside hydrolase, family 32

3 of 3

2.23

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00640

Glycosyl hydrolases family 32

3 of 3

2.23

1.9

0.00023

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