CHISP_1552 protein (Chitinispirillum alkaliphilum)

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CHISP_1552

Hypothetical protein. (307 aa)

Predicted Functional Partners:

CHISP_1555

0.916

CHISP_1074

0.844

CHISP_1270

0.844

CHISP_1331

0.844

CHISP_1724

0.844

CHISP_1735

0.844

CHISP_1557

0.782

CHISP_1554

0.774

CHISP_1556

0.774

CHISP_1553

0.773

Your Current Organism:

Chitinispirillum alkaliphilum

NCBI taxonomy Id: 1008392
Other names: C. alkaliphilum, Chitinispirillum alkaliphilum Sorokin et al. 2016, DSM 24539, UNIQEM U893, haloalkaliphilic bacterium ACht6-1, strain ACht6-1

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CHISP_1074	CHISP_1270	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase family 2.	0.985
CHISP_1074	CHISP_1331	Undecaprenyl-phosphate galactosephosphotransferase.	Undecaprenyl-phosphate galactosephosphotransferase.	0.857
CHISP_1074	CHISP_1552	Undecaprenyl-phosphate galactosephosphotransferase.	Hypothetical protein.	0.844
CHISP_1074	CHISP_1557	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase, group 2 family protein.	0.443
CHISP_1074	CHISP_1724	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase, family 2.	0.986
CHISP_1074	CHISP_1735	Undecaprenyl-phosphate galactosephosphotransferase.	Undecaprenyl-phosphate glucose phosphotransferase.	0.863
CHISP_1270	CHISP_1074	Glycosyl transferase family 2.	Undecaprenyl-phosphate galactosephosphotransferase.	0.985
CHISP_1270	CHISP_1331	Glycosyl transferase family 2.	Undecaprenyl-phosphate galactosephosphotransferase.	0.985
CHISP_1270	CHISP_1552	Glycosyl transferase family 2.	Hypothetical protein.	0.844
CHISP_1270	CHISP_1555	Glycosyl transferase family 2.	Glycosyl transferase, group 1 family protein.	0.515
CHISP_1270	CHISP_1556	Glycosyl transferase family 2.	Glycosyl transferase, group 1 family protein.	0.614
CHISP_1270	CHISP_1557	Glycosyl transferase family 2.	Glycosyl transferase, group 2 family protein.	0.660
CHISP_1270	CHISP_1724	Glycosyl transferase family 2.	Glycosyl transferase, family 2.	0.999
CHISP_1270	CHISP_1735	Glycosyl transferase family 2.	Undecaprenyl-phosphate glucose phosphotransferase.	0.988
CHISP_1331	CHISP_1074	Undecaprenyl-phosphate galactosephosphotransferase.	Undecaprenyl-phosphate galactosephosphotransferase.	0.857
CHISP_1331	CHISP_1270	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase family 2.	0.985
CHISP_1331	CHISP_1552	Undecaprenyl-phosphate galactosephosphotransferase.	Hypothetical protein.	0.844
CHISP_1331	CHISP_1557	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase, group 2 family protein.	0.445
CHISP_1331	CHISP_1724	Undecaprenyl-phosphate galactosephosphotransferase.	Glycosyl transferase, family 2.	0.988
CHISP_1331	CHISP_1735	Undecaprenyl-phosphate galactosephosphotransferase.	Undecaprenyl-phosphate glucose phosphotransferase.	0.866

page 1 of 4

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.387

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

7 of 14

2.21

4.8

3.68e-11

GO:0006091

Generation of precursor metabolites and energy

9 of 117

1.39

2.25

1.97e-09

GO:0044238

Primary metabolic process

10 of 1191

0.43

0.3

0.0287

GO:0044237

Cellular metabolic process

11 of 1480

0.38

0.29

0.0162

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000104

Succinate dehydrogenase activity

4 of 4

2.51

2.95

2.61e-06

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.51

1.03

0.0130

GO:0004775

succinate-CoA ligase (ADP-forming) activity

2 of 2

2.51

1.03

0.0130

GO:0016417

S-acyltransferase activity

2 of 5

2.11

0.94

0.0170

GO:0043169

Cation binding

7 of 452

0.7

0.46

0.0151

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

4 of 26

1.69

1.68

0.00017

GO:0045239

Tricarboxylic acid cycle enzyme complex

2 of 3

2.33

1.31

0.0037

GO:1902494

Catalytic complex

5 of 88

1.26

1.21

0.00029

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28827812

(2017) Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of alpha-ketoglutarate.

2 of 7

1.96

0.79

0.0316

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1043

Succinate dehydrogenase activity, and succinate-CoA ligase activity

6 of 6

2.51

5.25

3.91e-11

CL:997

Citrate cycle (TCA cycle), and Malic enzyme activity

9 of 29

2.0

5.22

3.09e-14

CL:999

acetyl-CoA metabolic process, and Dihydrolipoyl dehydrogenase activity

3 of 13

1.87

1.43

0.0013

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pga00020

Citrate cycle (TCA cycle)

9 of 25

2.06

5.84

1.34e-15

pga01200

Carbon metabolism

11 of 117

1.48

3.12

5.07e-15

pga01120

Microbial metabolism in diverse environments

11 of 235

1.18

1.82

5.53e-12

pga00650

Butanoate metabolism

4 of 37

1.54

1.63

9.01e-05

pga00190

Oxidative phosphorylation

4 of 45

1.45

1.47

0.00016

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

5 of 7

2.36

3.84

2.39e-08

GOCC:0045273

Respiratory chain complex II

3 of 3

2.51

2.23

6.76e-05

GOCC:0045252

Oxoglutarate dehydrogenase complex

3 of 4

2.38

2.19

7.11e-05

GOCC:1990204

Oxidoreductase complex

5 of 59

1.43

1.54

7.11e-05

GOCC:0045283

Fumarate reductase complex

2 of 2

2.51

1.49

0.0018

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

4 of 9

2.15

2.55

7.66e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01127

Succinate dehydrogenase/Fumarate reductase transmembrane subunit

2 of 2

2.51

0.86

0.0272

PF00549

CoA-ligase

2 of 2

2.51

0.86

0.0272

PF02817

e3 binding domain

2 of 3

2.33

0.85

0.0272

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 3

2.33

0.85

0.0272

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