CHISP_2095 protein (Chitinispirillum alkaliphilum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CHISP_2095

Phosphoglycolate phosphatase. (215 aa)

Predicted Functional Partners:

CHISP_1766

0.712

CHISP_2880

0.700

CHISP_3351

0.696

CHISP_2629

0.694

CHISP_0010

0.665

CHISP_0179

0.649

CHISP_1611

0.625

CHISP_1862

0.623

CHISP_0980

0.620

CHISP_0071

0.607

Your Current Organism:

Chitinispirillum alkaliphilum

NCBI taxonomy Id: 1008392
Other names: C. alkaliphilum, Chitinispirillum alkaliphilum Sorokin et al. 2016, DSM 24539, UNIQEM U893, haloalkaliphilic bacterium ACht6-1, strain ACht6-1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
CHISP_0010	CHISP_0071	Protein of unknown function DUF1121.	Anaerobic sulfite reductase subunit A.	0.950
CHISP_0010	CHISP_2095	Protein of unknown function DUF1121.	Phosphoglycolate phosphatase.	0.665
CHISP_0071	CHISP_0010	Anaerobic sulfite reductase subunit A.	Protein of unknown function DUF1121.	0.950
CHISP_0071	CHISP_0980	Anaerobic sulfite reductase subunit A.	Hypothetical protein.	0.561
CHISP_0071	CHISP_2095	Anaerobic sulfite reductase subunit A.	Phosphoglycolate phosphatase.	0.607
CHISP_0071	CHISP_2880	Anaerobic sulfite reductase subunit A.	Fumarate hydratase subunit beta.	0.647
CHISP_0179	CHISP_2095	Outer membrane assembly protein.	Phosphoglycolate phosphatase.	0.649
CHISP_0179	CHISP_3351	Outer membrane assembly protein.	Inosine-5'-monophosphate dehydrogenase.	0.639
CHISP_0980	CHISP_0071	Hypothetical protein.	Anaerobic sulfite reductase subunit A.	0.561
CHISP_0980	CHISP_1611	Hypothetical protein.	Trehalose 6-phosphate phosphorylase.	0.716
CHISP_0980	CHISP_1766	Hypothetical protein.	Damage-inducible protein CinA.	0.750
CHISP_0980	CHISP_2095	Hypothetical protein.	Phosphoglycolate phosphatase.	0.620
CHISP_0980	CHISP_3351	Hypothetical protein.	Inosine-5'-monophosphate dehydrogenase.	0.797
CHISP_1611	CHISP_0980	Trehalose 6-phosphate phosphorylase.	Hypothetical protein.	0.716
CHISP_1611	CHISP_1766	Trehalose 6-phosphate phosphorylase.	Damage-inducible protein CinA.	0.722
CHISP_1611	CHISP_2095	Trehalose 6-phosphate phosphorylase.	Phosphoglycolate phosphatase.	0.625
CHISP_1611	CHISP_3351	Trehalose 6-phosphate phosphorylase.	Inosine-5'-monophosphate dehydrogenase.	0.702
CHISP_1766	CHISP_0980	Damage-inducible protein CinA.	Hypothetical protein.	0.750
CHISP_1766	CHISP_1611	Damage-inducible protein CinA.	Trehalose 6-phosphate phosphorylase.	0.722
CHISP_1766	CHISP_2095	Damage-inducible protein CinA.	Phosphoglycolate phosphatase.	0.712

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.387

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

7 of 14

2.21

4.8

3.68e-11

GO:0006091

Generation of precursor metabolites and energy

9 of 117

1.39

2.25

1.97e-09

GO:0044238

Primary metabolic process

10 of 1191

0.43

0.3

0.0287

GO:0044237

Cellular metabolic process

11 of 1480

0.38

0.29

0.0162

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000104

Succinate dehydrogenase activity

4 of 4

2.51

2.95

2.61e-06

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.51

1.03

0.0130

GO:0004775

succinate-CoA ligase (ADP-forming) activity

2 of 2

2.51

1.03

0.0130

GO:0016417

S-acyltransferase activity

2 of 5

2.11

0.94

0.0170

GO:0043169

Cation binding

7 of 452

0.7

0.46

0.0151

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

4 of 26

1.69

1.68

0.00017

GO:0045239

Tricarboxylic acid cycle enzyme complex

2 of 3

2.33

1.31

0.0037

GO:1902494

Catalytic complex

5 of 88

1.26

1.21

0.00029

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28827812

(2017) Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of alpha-ketoglutarate.

2 of 7

1.96

0.79

0.0316

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1043

Succinate dehydrogenase activity, and succinate-CoA ligase activity

6 of 6

2.51

5.25

3.91e-11

CL:997

Citrate cycle (TCA cycle), and Malic enzyme activity

9 of 29

2.0

5.22

3.09e-14

CL:999

acetyl-CoA metabolic process, and Dihydrolipoyl dehydrogenase activity

3 of 13

1.87

1.43

0.0013

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pga00020

Citrate cycle (TCA cycle)

9 of 25

2.06

5.84

1.34e-15

pga01200

Carbon metabolism

11 of 117

1.48

3.12

5.07e-15

pga01120

Microbial metabolism in diverse environments

11 of 235

1.18

1.82

5.53e-12

pga00650

Butanoate metabolism

4 of 37

1.54

1.63

9.01e-05

pga00190

Oxidative phosphorylation

4 of 45

1.45

1.47

0.00016

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

5 of 7

2.36

3.84

2.39e-08

GOCC:0045273

Respiratory chain complex II

3 of 3

2.51

2.23

6.76e-05

GOCC:0045252

Oxoglutarate dehydrogenase complex

3 of 4

2.38

2.19

7.11e-05

GOCC:1990204

Oxidoreductase complex

5 of 59

1.43

1.54

7.11e-05

GOCC:0045283

Fumarate reductase complex

2 of 2

2.51

1.49

0.0018

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

4 of 9

2.15

2.55

7.66e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01127

Succinate dehydrogenase/Fumarate reductase transmembrane subunit

2 of 2

2.51

0.86

0.0272

PF00549

CoA-ligase

2 of 2

2.51

0.86

0.0272

PF02817

e3 binding domain

2 of 3

2.33

0.85

0.0272

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 3

2.33

0.85

0.0272

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About