node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clcf1 | Clcn4 | ENSMUSP00000045562 | ENSMUSP00000000619 | Cardiotrophin-like cytokine factor 1; In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.515 |
Clcn4 | Clcf1 | ENSMUSP00000000619 | ENSMUSP00000045562 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Cardiotrophin-like cytokine factor 1; In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. | 0.515 |
Clcn4 | Clcn6 | ENSMUSP00000000619 | ENSMUSP00000030879 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | 0.494 |
Clcn4 | Clic4 | ENSMUSP00000000619 | ENSMUSP00000041453 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis. | 0.459 |
Clcn4 | Gpr153 | ENSMUSP00000000619 | ENSMUSP00000101276 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.457 |
Clcn4 | Itsn2 | ENSMUSP00000000619 | ENSMUSP00000052758 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.456 |
Clcn4 | Ostm1 | ENSMUSP00000000619 | ENSMUSP00000035516 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function. | 0.702 |
Clcn4 | Pcgf3 | ENSMUSP00000000619 | ENSMUSP00000041790 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex th [...] | 0.454 |
Clcn4 | Phf6 | ENSMUSP00000000619 | ENSMUSP00000077971 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. | 0.555 |
Clcn4 | Pigk | ENSMUSP00000000619 | ENSMUSP00000045351 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). | 0.477 |
Clcn4 | Rnf123 | ENSMUSP00000000619 | ENSMUSP00000125745 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. | 0.454 |
Clcn6 | Clcn4 | ENSMUSP00000030879 | ENSMUSP00000000619 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.494 |
Clcn6 | Ostm1 | ENSMUSP00000030879 | ENSMUSP00000035516 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function. | 0.883 |
Clic4 | Clcn4 | ENSMUSP00000041453 | ENSMUSP00000000619 | Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.459 |
Gpr153 | Clcn4 | ENSMUSP00000101276 | ENSMUSP00000000619 | Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.457 |
Itsn2 | Clcn4 | ENSMUSP00000052758 | ENSMUSP00000000619 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.456 |
Ostm1 | Clcn4 | ENSMUSP00000035516 | ENSMUSP00000000619 | Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.702 |
Ostm1 | Clcn6 | ENSMUSP00000035516 | ENSMUSP00000030879 | Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function. | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | 0.883 |
Pcgf3 | Clcn4 | ENSMUSP00000041790 | ENSMUSP00000000619 | Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex th [...] | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.454 |
Phf6 | Clcn4 | ENSMUSP00000077971 | ENSMUSP00000000619 | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily. | 0.555 |