node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cbs | Cnnm3 | ENSMUSP00000158269 | ENSMUSP00000001166 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Metal transporter CNNM3; Probable metal transporter. | 0.501 |
Cbs | Mrs2 | ENSMUSP00000158269 | ENSMUSP00000021772 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | 0.405 |
Cnnm3 | Cbs | ENSMUSP00000001166 | ENSMUSP00000158269 | Metal transporter CNNM3; Probable metal transporter. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.501 |
Cnnm3 | Mrs2 | ENSMUSP00000001166 | ENSMUSP00000021772 | Metal transporter CNNM3; Probable metal transporter. | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | 0.517 |
Cnnm3 | Ptp4a1 | ENSMUSP00000001166 | ENSMUSP00000027232 | Metal transporter CNNM3; Probable metal transporter. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). | 0.638 |
Cnnm3 | Ptp4a1-2 | ENSMUSP00000001166 | ENSMUSP00000156862 | Metal transporter CNNM3; Probable metal transporter. | Protein tyrosine phosphatase 4a1. | 0.621 |
Cnnm3 | Ptp4a2 | ENSMUSP00000001166 | ENSMUSP00000030578 | Metal transporter CNNM3; Probable metal transporter. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity). | 0.867 |
Cnnm3 | Ptp4a3 | ENSMUSP00000001166 | ENSMUSP00000132097 | Metal transporter CNNM3; Probable metal transporter. | Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. | 0.824 |
Cnnm3 | Slc41a1 | ENSMUSP00000001166 | ENSMUSP00000083747 | Metal transporter CNNM3; Probable metal transporter. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family. | 0.662 |
Cnnm3 | Slc41a2 | ENSMUSP00000001166 | ENSMUSP00000036690 | Metal transporter CNNM3; Probable metal transporter. | Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family. | 0.613 |
Cnnm3 | Slc41a3 | ENSMUSP00000001166 | ENSMUSP00000037473 | Metal transporter CNNM3; Probable metal transporter. | Solute carrier family 41 member 3; Belongs to the SLC41A transporter family. | 0.551 |
Cnnm3 | Trpm6 | ENSMUSP00000001166 | ENSMUSP00000037443 | Metal transporter CNNM3; Probable metal transporter. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity); In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.599 |
Mrs2 | Cbs | ENSMUSP00000021772 | ENSMUSP00000158269 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.405 |
Mrs2 | Cnnm3 | ENSMUSP00000021772 | ENSMUSP00000001166 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Metal transporter CNNM3; Probable metal transporter. | 0.517 |
Mrs2 | Slc41a1 | ENSMUSP00000021772 | ENSMUSP00000083747 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family. | 0.689 |
Mrs2 | Slc41a2 | ENSMUSP00000021772 | ENSMUSP00000036690 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family. | 0.703 |
Mrs2 | Slc41a3 | ENSMUSP00000021772 | ENSMUSP00000037473 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Solute carrier family 41 member 3; Belongs to the SLC41A transporter family. | 0.713 |
Mrs2 | Trpm6 | ENSMUSP00000021772 | ENSMUSP00000037443 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity); In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.623 |
Ptp4a1 | Cnnm3 | ENSMUSP00000027232 | ENSMUSP00000001166 | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). | Metal transporter CNNM3; Probable metal transporter. | 0.638 |
Ptp4a1-2 | Cnnm3 | ENSMUSP00000156862 | ENSMUSP00000001166 | Protein tyrosine phosphatase 4a1. | Metal transporter CNNM3; Probable metal transporter. | 0.621 |