STRINGSTRING
Ddx18 protein (mouse) - STRING interaction network
"Ddx18" - ATP-dependent RNA helicase DDX18 in Mus musculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
Ddx18ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily (660 aa)    
Predicted Functional Partners:
Nop2
Probable 28S rRNA (cytosine-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S- adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (794 aa)
     
 
  0.980
Nifk
Nucleolar protein interacting with the FHA domain of MKI67 (317 aa)
     
 
  0.978
Rpf1
Ribosome production factor 1; May be required for ribosome biogenesis (349 aa)
     
 
  0.978
Bop1
Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (732 aa)
     
 
  0.977
Dkc1
H/ACA ribonucleoprotein complex subunit 4; Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase r [...] (509 aa)
   
 
  0.975
Nop58
Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity); Belongs to the NOP5/NOP56 family (536 aa)
   
 
  0.974
Brix1
Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit (353 aa)
     
 
  0.970
Gtpbp4
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (634 aa)
     
 
  0.968
Tbl3
Transducin (beta)-like 3 (801 aa)
     
 
  0.968
Rpf2
Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus (273 aa)
     
 
  0.967
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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