node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crebl2 | Metrn | ENSMUSP00000035304 | ENSMUSP00000127275 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | 0.432 |
Fam173a | Metrn | ENSMUSP00000072518 | ENSMUSP00000127275 | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | 0.538 |
Fgf21 | Fndc5 | ENSMUSP00000033099 | ENSMUSP00000099660 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | 0.751 |
Fgf21 | Metrn | ENSMUSP00000033099 | ENSMUSP00000127275 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | 0.519 |
Fgf21 | Mstn | ENSMUSP00000033099 | ENSMUSP00000027269 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. | 0.535 |
Fgf21 | Ucp1 | ENSMUSP00000033099 | ENSMUSP00000034146 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.748 |
Fndc5 | Fgf21 | ENSMUSP00000099660 | ENSMUSP00000033099 | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | 0.751 |
Fndc5 | Metrn | ENSMUSP00000099660 | ENSMUSP00000127275 | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | 0.711 |
Fndc5 | Mstn | ENSMUSP00000099660 | ENSMUSP00000027269 | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. | 0.743 |
Fndc5 | Ucp1 | ENSMUSP00000099660 | ENSMUSP00000034146 | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.735 |
Kbtbd12 | Metrn | ENSMUSP00000112581 | ENSMUSP00000127275 | Kelch repeat and BTB domain-containing protein 12. | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | 0.485 |
Kbtbd12 | Rrp36 | ENSMUSP00000112581 | ENSMUSP00000024766 | Kelch repeat and BTB domain-containing protein 12. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family. | 0.672 |
Kbtbd12 | Sipa1l2 | ENSMUSP00000112581 | ENSMUSP00000148536 | Kelch repeat and BTB domain-containing protein 12. | Signal-induced proliferation-associated 1-like protein 2. | 0.592 |
Metrn | Crebl2 | ENSMUSP00000127275 | ENSMUSP00000035304 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. | 0.432 |
Metrn | Fam173a | ENSMUSP00000127275 | ENSMUSP00000072518 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4. | 0.538 |
Metrn | Fgf21 | ENSMUSP00000127275 | ENSMUSP00000033099 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | 0.519 |
Metrn | Fndc5 | ENSMUSP00000127275 | ENSMUSP00000099660 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. | 0.711 |
Metrn | Kbtbd12 | ENSMUSP00000127275 | ENSMUSP00000112581 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Kelch repeat and BTB domain-containing protein 12. | 0.485 |
Metrn | Mstn | ENSMUSP00000127275 | ENSMUSP00000027269 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. | 0.483 |
Metrn | Rrp36 | ENSMUSP00000127275 | ENSMUSP00000024766 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family. | 0.472 |