node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alg2 | Dhrs1 | ENSMUSP00000043580 | ENSMUSP00000002403 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.449 |
Cox18 | Dhrs1 | ENSMUSP00000113353 | ENSMUSP00000002403 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.580 |
Cox18 | Rrn3 | ENSMUSP00000113353 | ENSMUSP00000023363 | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family. | 0.494 |
Dhrs1 | Alg2 | ENSMUSP00000002403 | ENSMUSP00000043580 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. | 0.449 |
Dhrs1 | Cox18 | ENSMUSP00000002403 | ENSMUSP00000113353 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). | 0.580 |
Dhrs1 | Dhrs7b | ENSMUSP00000002403 | ENSMUSP00000044924 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase. | 0.578 |
Dhrs1 | Etfa | ENSMUSP00000002403 | ENSMUSP00000034866 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.443 |
Dhrs1 | Etfrf1 | ENSMUSP00000002403 | ENSMUSP00000039433 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). | 0.443 |
Dhrs1 | Fbxl8 | ENSMUSP00000002403 | ENSMUSP00000038638 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.547 |
Dhrs1 | Med14 | ENSMUSP00000002403 | ENSMUSP00000094239 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.444 |
Dhrs1 | Ndufs2 | ENSMUSP00000002403 | ENSMUSP00000013737 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.455 |
Dhrs1 | Oxsm | ENSMUSP00000002403 | ENSMUSP00000022311 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. | 0.433 |
Dhrs1 | Rrn3 | ENSMUSP00000002403 | ENSMUSP00000023363 | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family. | 0.610 |
Dhrs7b | Dhrs1 | ENSMUSP00000044924 | ENSMUSP00000002403 | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase. | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.578 |
Dhrs7b | Oxsm | ENSMUSP00000044924 | ENSMUSP00000022311 | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. | 0.430 |
Etfa | Dhrs1 | ENSMUSP00000034866 | ENSMUSP00000002403 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.443 |
Etfa | Etfrf1 | ENSMUSP00000034866 | ENSMUSP00000039433 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). | 0.882 |
Etfa | Ndufs2 | ENSMUSP00000034866 | ENSMUSP00000013737 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.586 |
Etfa | Oxsm | ENSMUSP00000034866 | ENSMUSP00000022311 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. | 0.566 |
Etfrf1 | Dhrs1 | ENSMUSP00000039433 | ENSMUSP00000002403 | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). | Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.443 |