node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agxt | Alas2 | ENSMUSP00000027491 | ENSMUSP00000066040 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 0.923 |
Agxt | Dmgdh | ENSMUSP00000027491 | ENSMUSP00000039663 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Dimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. | 0.649 |
Agxt | Gatm | ENSMUSP00000027491 | ENSMUSP00000028624 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. | 0.941 |
Agxt | Gcat | ENSMUSP00000027491 | ENSMUSP00000006544 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.933 |
Agxt | Gldc | ENSMUSP00000027491 | ENSMUSP00000025778 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.960 |
Agxt | Gnmt | ENSMUSP00000027491 | ENSMUSP00000002846 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.947 |
Agxt | Pipox | ENSMUSP00000027491 | ENSMUSP00000017597 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.965 |
Agxt | Sardh | ENSMUSP00000027491 | ENSMUSP00000099950 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.960 |
Agxt | Shmt1 | ENSMUSP00000027491 | ENSMUSP00000018744 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.977 |
Agxt | Shmt2 | ENSMUSP00000027491 | ENSMUSP00000026470 | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.959 |
Alas2 | Agxt | ENSMUSP00000066040 | ENSMUSP00000027491 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 0.923 |
Alas2 | Gatm | ENSMUSP00000066040 | ENSMUSP00000028624 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. | 0.904 |
Alas2 | Gcat | ENSMUSP00000066040 | ENSMUSP00000006544 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.911 |
Alas2 | Gldc | ENSMUSP00000066040 | ENSMUSP00000025778 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.929 |
Alas2 | Gnmt | ENSMUSP00000066040 | ENSMUSP00000002846 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. | 0.913 |
Alas2 | Pipox | ENSMUSP00000066040 | ENSMUSP00000017597 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.925 |
Alas2 | Sardh | ENSMUSP00000066040 | ENSMUSP00000099950 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family. | 0.936 |
Alas2 | Shmt1 | ENSMUSP00000066040 | ENSMUSP00000018744 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.918 |
Alas2 | Shmt2 | ENSMUSP00000066040 | ENSMUSP00000026470 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.924 |
Dmgdh | Agxt | ENSMUSP00000039663 | ENSMUSP00000027491 | Dimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. | Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). | 0.649 |