node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh1l2 | Amt | ENSMUSP00000020497 | ENSMUSP00000035230 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.937 |
Aldh1l2 | Atic | ENSMUSP00000020497 | ENSMUSP00000027384 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.511 |
Aldh1l2 | Gart | ENSMUSP00000020497 | ENSMUSP00000023684 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.956 |
Aldh1l2 | Mthfd1l | ENSMUSP00000020497 | ENSMUSP00000112897 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.651 |
Aldh1l2 | Mthfd2 | ENSMUSP00000020497 | ENSMUSP00000005810 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.974 |
Aldh1l2 | Mthfr | ENSMUSP00000020497 | ENSMUSP00000069774 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | 0.525 |
Aldh1l2 | Shmt1 | ENSMUSP00000020497 | ENSMUSP00000018744 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.955 |
Aldh1l2 | Shmt2 | ENSMUSP00000020497 | ENSMUSP00000026470 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.968 |
Amt | Aldh1l2 | ENSMUSP00000035230 | ENSMUSP00000020497 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | 0.937 |
Amt | Atic | ENSMUSP00000035230 | ENSMUSP00000027384 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.966 |
Amt | Gart | ENSMUSP00000035230 | ENSMUSP00000023684 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.965 |
Amt | Mtfmt | ENSMUSP00000035230 | ENSMUSP00000074347 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity); Belongs to the Fmt family. | 0.932 |
Amt | Mthfd1l | ENSMUSP00000035230 | ENSMUSP00000112897 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. | 0.966 |
Amt | Mthfd2 | ENSMUSP00000035230 | ENSMUSP00000005810 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. | 0.981 |
Amt | Mthfr | ENSMUSP00000035230 | ENSMUSP00000069774 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. | 0.965 |
Amt | Shmt1 | ENSMUSP00000035230 | ENSMUSP00000018744 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.977 |
Amt | Shmt2 | ENSMUSP00000035230 | ENSMUSP00000026470 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] | 0.978 |
Amt | Tyms | ENSMUSP00000035230 | ENSMUSP00000026846 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.934 |
Atic | Aldh1l2 | ENSMUSP00000027384 | ENSMUSP00000020497 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. | 0.511 |
Atic | Amt | ENSMUSP00000027384 | ENSMUSP00000035230 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.966 |