| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Anpep | Gclc | ENSMUSP00000103015 | ENSMUSP00000034905 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | 0.953 |
| Anpep | Ggct | ENSMUSP00000103015 | ENSMUSP00000120154 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. | 0.877 |
| Anpep | Ggt1 | ENSMUSP00000103015 | ENSMUSP00000006508 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.954 |
| Anpep | Ggt5 | ENSMUSP00000103015 | ENSMUSP00000072074 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.946 |
| Anpep | Ggt6 | ENSMUSP00000103015 | ENSMUSP00000075773 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.958 |
| Anpep | Ggt7 | ENSMUSP00000103015 | ENSMUSP00000029131 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.944 |
| Anpep | Gss | ENSMUSP00000103015 | ENSMUSP00000078630 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. | 0.880 |
| Anpep | Lap3 | ENSMUSP00000103015 | ENSMUSP00000040222 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). | 0.941 |
| Gclc | Anpep | ENSMUSP00000034905 | ENSMUSP00000103015 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | 0.953 |
| Gclc | Ggct | ENSMUSP00000034905 | ENSMUSP00000120154 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. | 0.914 |
| Gclc | Ggt1 | ENSMUSP00000034905 | ENSMUSP00000006508 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] | 0.928 |
| Gclc | Ggt5 | ENSMUSP00000034905 | ENSMUSP00000072074 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.899 |
| Gclc | Ggt6 | ENSMUSP00000034905 | ENSMUSP00000075773 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.943 |
| Gclc | Ggt7 | ENSMUSP00000034905 | ENSMUSP00000029131 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.917 |
| Gclc | Gsr | ENSMUSP00000034905 | ENSMUSP00000033992 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | 0.894 |
| Gclc | Gss | ENSMUSP00000034905 | ENSMUSP00000078630 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. | 0.991 |
| Gclc | Lap3 | ENSMUSP00000034905 | ENSMUSP00000040222 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). | 0.910 |
| Gclc | Oplah | ENSMUSP00000034905 | ENSMUSP00000129100 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. | 0.952 |
| Ggct | Anpep | ENSMUSP00000120154 | ENSMUSP00000103015 | Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] | 0.877 |
| Ggct | Gclc | ENSMUSP00000120154 | ENSMUSP00000034905 | Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | 0.914 |
