node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Afdn | Nectin1 | ENSMUSP00000118318 | ENSMUSP00000034510 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Nectin-1; Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Belongs to the nectin family. | 0.996 |
Afdn | Nectin2 | ENSMUSP00000118318 | ENSMUSP00000074898 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. | 0.996 |
Afdn | Nectin3 | ENSMUSP00000118318 | ENSMUSP00000023334 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morpholog [...] | 0.998 |
Afdn | Nectin4 | ENSMUSP00000118318 | ENSMUSP00000006578 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. | 0.915 |
Afdn | Pard3 | ENSMUSP00000118318 | ENSMUSP00000125453 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon [...] | 0.631 |
Afdn | Slamf1 | ENSMUSP00000118318 | ENSMUSP00000015460 | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] | 0.482 |
Ankrd22 | Nectin4 | ENSMUSP00000025686 | ENSMUSP00000006578 | Ankyrin repeat domain-containing protein 22. | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. | 0.466 |
Cd46 | Hpd | ENSMUSP00000123931 | ENSMUSP00000031398 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.452 |
Cd46 | Mybph | ENSMUSP00000123931 | ENSMUSP00000141104 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | 0.847 |
Cd46 | Nectin4 | ENSMUSP00000123931 | ENSMUSP00000006578 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. | 0.643 |
Cd46 | Slamf1 | ENSMUSP00000123931 | ENSMUSP00000015460 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] | 0.886 |
Hpd | Cd46 | ENSMUSP00000031398 | ENSMUSP00000123931 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.452 |
Hpd | Mybph | ENSMUSP00000031398 | ENSMUSP00000141104 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | 0.740 |
Hpd | Nectin4 | ENSMUSP00000031398 | ENSMUSP00000006578 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. | 0.477 |
Mybph | Cd46 | ENSMUSP00000141104 | ENSMUSP00000123931 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.847 |
Mybph | Hpd | ENSMUSP00000141104 | ENSMUSP00000031398 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family. | 0.740 |
Mybph | Nectin4 | ENSMUSP00000141104 | ENSMUSP00000006578 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. | 0.933 |
Mybph | Slamf1 | ENSMUSP00000141104 | ENSMUSP00000015460 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] | 0.826 |
Nectin1 | Afdn | ENSMUSP00000034510 | ENSMUSP00000118318 | Nectin-1; Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Belongs to the nectin family. | Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity). | 0.996 |
Nectin1 | Nectin2 | ENSMUSP00000034510 | ENSMUSP00000074898 | Nectin-1; Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Belongs to the nectin family. | Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. | 0.960 |