node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cars | Cars2 | ENSMUSP00000010899 | ENSMUSP00000046453 | Cysteine--tRNA ligase, cytoplasmic. | Probable cysteine--tRNA ligase, mitochondrial. | 0.912 |
Cars | Eprs | ENSMUSP00000010899 | ENSMUSP00000045841 | Cysteine--tRNA ligase, cytoplasmic. | Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex [...] | 0.890 |
Cars | Gars | ENSMUSP00000010899 | ENSMUSP00000003572 | Cysteine--tRNA ligase, cytoplasmic. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.866 |
Cars | Iars | ENSMUSP00000010899 | ENSMUSP00000132082 | Cysteine--tRNA ligase, cytoplasmic. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.885 |
Cars | Iars2 | ENSMUSP00000010899 | ENSMUSP00000027921 | Cysteine--tRNA ligase, cytoplasmic. | Isoleucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.873 |
Cars | Lars | ENSMUSP00000010899 | ENSMUSP00000095197 | Cysteine--tRNA ligase, cytoplasmic. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.942 |
Cars | Lars2 | ENSMUSP00000010899 | ENSMUSP00000036710 | Cysteine--tRNA ligase, cytoplasmic. | Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.897 |
Cars | Sars | ENSMUSP00000010899 | ENSMUSP00000099685 | Cysteine--tRNA ligase, cytoplasmic. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] | 0.902 |
Cars | Sars2 | ENSMUSP00000010899 | ENSMUSP00000092216 | Cysteine--tRNA ligase, cytoplasmic. | Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. | 0.887 |
Cars | Yars | ENSMUSP00000010899 | ENSMUSP00000101669 | Cysteine--tRNA ligase, cytoplasmic. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.899 |
Cars2 | Cars | ENSMUSP00000046453 | ENSMUSP00000010899 | Probable cysteine--tRNA ligase, mitochondrial. | Cysteine--tRNA ligase, cytoplasmic. | 0.912 |
Cars2 | Eprs | ENSMUSP00000046453 | ENSMUSP00000045841 | Probable cysteine--tRNA ligase, mitochondrial. | Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex [...] | 0.881 |
Cars2 | Gars | ENSMUSP00000046453 | ENSMUSP00000003572 | Probable cysteine--tRNA ligase, mitochondrial. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.726 |
Cars2 | Iars | ENSMUSP00000046453 | ENSMUSP00000132082 | Probable cysteine--tRNA ligase, mitochondrial. | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.845 |
Cars2 | Iars2 | ENSMUSP00000046453 | ENSMUSP00000027921 | Probable cysteine--tRNA ligase, mitochondrial. | Isoleucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.891 |
Cars2 | Lars | ENSMUSP00000046453 | ENSMUSP00000095197 | Probable cysteine--tRNA ligase, mitochondrial. | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.908 |
Cars2 | Lars2 | ENSMUSP00000046453 | ENSMUSP00000036710 | Probable cysteine--tRNA ligase, mitochondrial. | Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.917 |
Cars2 | Sars | ENSMUSP00000046453 | ENSMUSP00000099685 | Probable cysteine--tRNA ligase, mitochondrial. | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] | 0.852 |
Cars2 | Sars2 | ENSMUSP00000046453 | ENSMUSP00000092216 | Probable cysteine--tRNA ligase, mitochondrial. | Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. | 0.922 |
Cars2 | Yars | ENSMUSP00000046453 | ENSMUSP00000101669 | Probable cysteine--tRNA ligase, mitochondrial. | Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.866 |