node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Comt | Dgcr2 | ENSMUSP00000130077 | ENSMUSP00000012152 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 0.562 |
Comt | Gnb1l | ENSMUSP00000130077 | ENSMUSP00000087544 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Guanine nucleotide-binding protein subunit beta-like protein 1. | 0.638 |
Comt | Mrpl40 | ENSMUSP00000130077 | ENSMUSP00000023391 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 39S ribosomal protein L40, mitochondrial. | 0.474 |
Comt | Prodh | ENSMUSP00000130077 | ENSMUSP00000003620 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.841 |
Comt | Ranbp1 | ENSMUSP00000130077 | ENSMUSP00000111309 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Ran-specific GTPase-activating protein; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle asse [...] | 0.415 |
Comt | Trmt2a | ENSMUSP00000130077 | ENSMUSP00000111304 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | tRNA (uracil-5-)-methyltransferase homolog A. | 0.478 |
Comt | Ufd1 | ENSMUSP00000130077 | ENSMUSP00000111241 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] | 0.416 |
Comt | Zdhhc8 | ENSMUSP00000130077 | ENSMUSP00000076224 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.772 |
Dgcr2 | Comt | ENSMUSP00000012152 | ENSMUSP00000130077 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.562 |
Dgcr2 | Ess2 | ENSMUSP00000012152 | ENSMUSP00000003621 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | 0.837 |
Dgcr2 | Gnb1l | ENSMUSP00000012152 | ENSMUSP00000087544 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Guanine nucleotide-binding protein subunit beta-like protein 1. | 0.639 |
Dgcr2 | Hira | ENSMUSP00000012152 | ENSMUSP00000004222 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Protein HIRA; Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. | 0.568 |
Dgcr2 | Mrpl40 | ENSMUSP00000012152 | ENSMUSP00000023391 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 39S ribosomal protein L40, mitochondrial. | 0.628 |
Dgcr2 | Prodh | ENSMUSP00000012152 | ENSMUSP00000003620 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. | 0.787 |
Dgcr2 | Ranbp1 | ENSMUSP00000012152 | ENSMUSP00000111309 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Ran-specific GTPase-activating protein; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle asse [...] | 0.657 |
Dgcr2 | Trmt2a | ENSMUSP00000012152 | ENSMUSP00000111304 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | tRNA (uracil-5-)-methyltransferase homolog A. | 0.625 |
Dgcr2 | Ufd1 | ENSMUSP00000012152 | ENSMUSP00000111241 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] | 0.643 |
Dgcr2 | Zdhhc8 | ENSMUSP00000012152 | ENSMUSP00000076224 | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. | 0.795 |
Ess2 | Dgcr2 | ENSMUSP00000003621 | ENSMUSP00000012152 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals. | 0.837 |
Ess2 | Gnb1l | ENSMUSP00000003621 | ENSMUSP00000087544 | Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing. | Guanine nucleotide-binding protein subunit beta-like protein 1. | 0.400 |