node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap30 | Arhgap9 | ENSMUSP00000059389 | ENSMUSP00000151574 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Rho GTPase-activating protein 9. | 0.536 |
Arhgap30 | Sash3 | ENSMUSP00000059389 | ENSMUSP00000033427 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.734 |
Arhgap30 | Tnfaip8l2 | ENSMUSP00000059389 | ENSMUSP00000013851 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.400 |
Arhgap9 | Arhgap30 | ENSMUSP00000151574 | ENSMUSP00000059389 | Rho GTPase-activating protein 9. | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | 0.536 |
Arhgap9 | Cyth4 | ENSMUSP00000151574 | ENSMUSP00000042698 | Rho GTPase-activating protein 9. | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | 0.448 |
Arhgap9 | Sash3 | ENSMUSP00000151574 | ENSMUSP00000033427 | Rho GTPase-activating protein 9. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.661 |
Arhgap9 | Tnfaip8l2 | ENSMUSP00000151574 | ENSMUSP00000013851 | Rho GTPase-activating protein 9. | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.590 |
Casp8 | Tnf | ENSMUSP00000140546 | ENSMUSP00000025263 | Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.980 |
Casp8 | Tnfaip8l2 | ENSMUSP00000140546 | ENSMUSP00000013851 | Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.739 |
Cyth4 | Arhgap9 | ENSMUSP00000042698 | ENSMUSP00000151574 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Rho GTPase-activating protein 9. | 0.448 |
Cyth4 | Tnfaip8l2 | ENSMUSP00000042698 | ENSMUSP00000013851 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.489 |
Fbxw5 | Tnfaip8l2 | ENSMUSP00000015239 | ENSMUSP00000013851 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin- protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degrad [...] | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.411 |
Rpf2 | Tchhl1 | ENSMUSP00000138581 | ENSMUSP00000029516 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | Trichohyalin-like protein 1; Belongs to the S-100 family. | 0.610 |
Rpf2 | Tnfaip8l2 | ENSMUSP00000138581 | ENSMUSP00000013851 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.470 |
Sash3 | Arhgap30 | ENSMUSP00000033427 | ENSMUSP00000059389 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | 0.734 |
Sash3 | Arhgap9 | ENSMUSP00000033427 | ENSMUSP00000151574 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | Rho GTPase-activating protein 9. | 0.661 |
Sash3 | Tnfaip8l2 | ENSMUSP00000033427 | ENSMUSP00000013851 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.492 |
Sash3 | Tyrobp | ENSMUSP00000033427 | ENSMUSP00000032800 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine- phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation [...] | 0.402 |
Tchhl1 | Rpf2 | ENSMUSP00000029516 | ENSMUSP00000138581 | Trichohyalin-like protein 1; Belongs to the S-100 family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family. | 0.610 |
Tchhl1 | Tnfaip8l2 | ENSMUSP00000029516 | ENSMUSP00000013851 | Trichohyalin-like protein 1; Belongs to the S-100 family. | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. | 0.461 |