node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd55b | Prss28 | ENSMUSP00000108107 | ENSMUSP00000015267 | Complement decay-accelerating factor transmembrane isoform; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing th [...] | Serine protease 28; Involved in embryo hatching and implantation. | 0.437 |
Cd55b | Sh2d1b1 | ENSMUSP00000108107 | ENSMUSP00000137069 | Complement decay-accelerating factor transmembrane isoform; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing th [...] | SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of CD244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter fou [...] | 0.609 |
Cetn1 | Morn1 | ENSMUSP00000057392 | ENSMUSP00000030915 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | MORN repeat-containing 1. | 0.747 |
Cetn1 | Prss28 | ENSMUSP00000057392 | ENSMUSP00000015267 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | Serine protease 28; Involved in embryo hatching and implantation. | 0.493 |
Clk1 | Prss28 | ENSMUSP00000034868 | ENSMUSP00000015267 | Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. | Serine protease 28; Involved in embryo hatching and implantation. | 0.642 |
Clk1 | Surf1 | ENSMUSP00000034868 | ENSMUSP00000015934 | Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. | Surfeit locus protein 1; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 0.614 |
Gm2001 | Prss28 | ENSMUSP00000152093 | ENSMUSP00000015267 | Ubiquitin-like protein 5. | Serine protease 28; Involved in embryo hatching and implantation. | 0.410 |
Morn1 | Cetn1 | ENSMUSP00000030915 | ENSMUSP00000057392 | MORN repeat-containing 1. | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | 0.747 |
Morn1 | Prss28 | ENSMUSP00000030915 | ENSMUSP00000015267 | MORN repeat-containing 1. | Serine protease 28; Involved in embryo hatching and implantation. | 0.696 |
Prss28 | Cd55b | ENSMUSP00000015267 | ENSMUSP00000108107 | Serine protease 28; Involved in embryo hatching and implantation. | Complement decay-accelerating factor transmembrane isoform; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing th [...] | 0.437 |
Prss28 | Cetn1 | ENSMUSP00000015267 | ENSMUSP00000057392 | Serine protease 28; Involved in embryo hatching and implantation. | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation ; Belongs to the centrin family. | 0.493 |
Prss28 | Clk1 | ENSMUSP00000015267 | ENSMUSP00000034868 | Serine protease 28; Involved in embryo hatching and implantation. | Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. | 0.642 |
Prss28 | Gm2001 | ENSMUSP00000015267 | ENSMUSP00000152093 | Serine protease 28; Involved in embryo hatching and implantation. | Ubiquitin-like protein 5. | 0.410 |
Prss28 | Morn1 | ENSMUSP00000015267 | ENSMUSP00000030915 | Serine protease 28; Involved in embryo hatching and implantation. | MORN repeat-containing 1. | 0.696 |
Prss28 | Sh2d1b1 | ENSMUSP00000015267 | ENSMUSP00000137069 | Serine protease 28; Involved in embryo hatching and implantation. | SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of CD244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter fou [...] | 0.465 |
Prss28 | Spink1 | ENSMUSP00000015267 | ENSMUSP00000025381 | Serine protease 28; Involved in embryo hatching and implantation. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. | 0.448 |
Prss28 | Surf1 | ENSMUSP00000015267 | ENSMUSP00000015934 | Serine protease 28; Involved in embryo hatching and implantation. | Surfeit locus protein 1; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. | 0.410 |
Prss28 | Ubl5 | ENSMUSP00000015267 | ENSMUSP00000125540 | Serine protease 28; Involved in embryo hatching and implantation. | Ubiquitin-like protein 5. | 0.453 |
Sh2d1b1 | Cd55b | ENSMUSP00000137069 | ENSMUSP00000108107 | SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of CD244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter fou [...] | Complement decay-accelerating factor transmembrane isoform; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing th [...] | 0.609 |
Sh2d1b1 | Prss28 | ENSMUSP00000137069 | ENSMUSP00000015267 | SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of CD244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter fou [...] | Serine protease 28; Involved in embryo hatching and implantation. | 0.465 |