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Acadsb protein (mouse) - STRING interaction network
"Acadsb" - Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial in Mus musculus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AcadsbShort/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity) (432 aa)    
Predicted Functional Partners:
Echs1
Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family (290 aa)
 
  0.984
Ehhadh
Peroxisomal bifunctional enzyme; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family (718 aa)
   
  0.959
Acat1
Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism; Belongs to the thiolase family (424 aa)
   
 
  0.956
Acaa2
3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
   
 
  0.955
Acsl5
Long-chain-fatty-acid--CoA ligase 5; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL (By similarity). May have a role in [...] (683 aa)
   
  0.955
Hadha
Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family (763 aa)
   
  0.952
Acaa1b
3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-Coenzyme A acyltransferase 1B (424 aa)
   
 
  0.952
Acaa1a
3-ketoacyl-CoA thiolase A, peroxisomal; acetyl-Coenzyme A acyltransferase 1A (424 aa)
   
 
  0.950
Hadhb
Trifunctional enzyme subunit beta, mitochondrial; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (475 aa)
   
 
  0.950
Acat2
Acetyl-CoA acetyltransferase, cytosolic; acetyl-Coenzyme A acetyltransferase 2 (397 aa)
   
 
  0.946
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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