node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyp11a1 | Fshb | ENSMUSP00000034874 | ENSMUSP00000028533 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | 0.720 |
Cyp11a1 | Prl3c1 | ENSMUSP00000034874 | ENSMUSP00000018066 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | 0.575 |
Cyp11a1 | Prl8a1 | ENSMUSP00000034874 | ENSMUSP00000006664 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Prolactin family 8, subfamily a, member 1. | 0.535 |
Cyp11a1 | Prl8a2 | ENSMUSP00000034874 | ENSMUSP00000018403 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Prolactin family 8, subfamily a, member 2. | 0.601 |
Cyp11a1 | Sp3 | ENSMUSP00000034874 | ENSMUSP00000099750 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity). | 0.540 |
Fshb | Cyp11a1 | ENSMUSP00000028533 | ENSMUSP00000034874 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.720 |
Fshb | Prl3c1 | ENSMUSP00000028533 | ENSMUSP00000018066 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | 0.645 |
Fshb | Prl5a1 | ENSMUSP00000028533 | ENSMUSP00000017208 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Prolactin-5A1. | 0.736 |
Fshb | Prl8a1 | ENSMUSP00000028533 | ENSMUSP00000006664 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Prolactin family 8, subfamily a, member 1. | 0.598 |
Fshb | Prl8a2 | ENSMUSP00000028533 | ENSMUSP00000018403 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Prolactin family 8, subfamily a, member 2. | 0.630 |
Fshb | Sp3 | ENSMUSP00000028533 | ENSMUSP00000099750 | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity). | 0.538 |
Pnma5 | Prl3c1 | ENSMUSP00000063061 | ENSMUSP00000018066 | Paraneoplastic antigen-like protein 5. | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | 0.607 |
Prl2c5 | Prl3c1 | ENSMUSP00000115024 | ENSMUSP00000018066 | Prolactin-2C5. | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | 0.579 |
Prl3c1 | Cyp11a1 | ENSMUSP00000018066 | ENSMUSP00000034874 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.575 |
Prl3c1 | Fshb | ENSMUSP00000018066 | ENSMUSP00000028533 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family. | 0.645 |
Prl3c1 | Pnma5 | ENSMUSP00000018066 | ENSMUSP00000063061 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Paraneoplastic antigen-like protein 5. | 0.607 |
Prl3c1 | Prl2c5 | ENSMUSP00000018066 | ENSMUSP00000115024 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Prolactin-2C5. | 0.579 |
Prl3c1 | Prl5a1 | ENSMUSP00000018066 | ENSMUSP00000017208 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Prolactin-5A1. | 0.631 |
Prl3c1 | Prl7a1 | ENSMUSP00000018066 | ENSMUSP00000093614 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Prolactin-7A1; Belongs to the somatotropin/prolactin family. | 0.778 |
Prl3c1 | Prl7a2 | ENSMUSP00000018066 | ENSMUSP00000006660 | Prolactin-3C1; Belongs to the somatotropin/prolactin family. | Prolactin-7A2. | 0.658 |