STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CryaaAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). (196 aa)    
Predicted Functional Partners:
Cryab
Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
   
0.993
Cryba1
Beta-crystallin A1; Crystallins are the dominant structural components of the vertebrate eye lens.
   
 
 0.969
Crybb2
Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens.
   
 
 0.965
Crygd
Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
   
 
 0.959
Crygs
Gamma-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens.
   
 
 0.952
Crybb1
Beta-crystallin B1B; Crystallins are the dominant structural components of the vertebrate eye lens.
   
  
 0.904
Crygc
Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens.
   
  
 0.900
Cryba2
Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens.
   
  
 0.899
Crygb
Gamma-crystallin B; Crystallins are the dominant structural components of the vertebrate eye lens.
   
 
 0.891
Crybb3
Beta-crystallin B3, N-terminally processed; Crystallins are the dominant structural components of the vertebrate eye lens.
   
  
 0.852
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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