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Mdh2 protein (mouse) - STRING interaction network
"Mdh2" - Malate dehydrogenase 2, NAD in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mdh2Malate dehydrogenase 2, NAD (mitochondrial) (338 aa)    
Predicted Functional Partners:
Fh1
Fumarate hydratase, mitochondrial; Fumarate hydratase 1 (507 aa)
   
  0.995
Cs
Citrate synthase, mitochondrial; Citrate synthase (464 aa)
   
  0.995
Got2
Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
     
  0.988
Csl
Citrate synthase like; Belongs to the citrate synthase family (466 aa)
   
  0.984
Pcx
Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1179 aa)
   
  0.984
Mdh1
Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1, NAD (soluble) (334 aa)
     
 
  0.972
Me2
Malic enzyme 2, NAD(+)-dependent, mitochondrial (589 aa)
   
  0.960
Me1
Malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa)
   
  0.960
Suclg1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits (346 aa)
   
   
  0.958
Acly
ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (By similarity); In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family (1101 aa)
   
  0.956
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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