node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cnn2 | Nrbp2 | ENSMUSP00000004784 | ENSMUSP00000019516 | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.514 |
Eppk1 | Nrbp2 | ENSMUSP00000154609 | ENSMUSP00000019516 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.484 |
Eppk1 | Tmem53 | ENSMUSP00000154609 | ENSMUSP00000102042 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.413 |
Lonp2 | Nrbp2 | ENSMUSP00000034141 | ENSMUSP00000019516 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.546 |
Lonp2 | Srfbp1 | ENSMUSP00000034141 | ENSMUSP00000025406 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. | Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. | 0.562 |
Nrbp2 | Cnn2 | ENSMUSP00000019516 | ENSMUSP00000004784 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. | 0.514 |
Nrbp2 | Eppk1 | ENSMUSP00000019516 | ENSMUSP00000154609 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] | 0.484 |
Nrbp2 | Lonp2 | ENSMUSP00000019516 | ENSMUSP00000034141 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. | 0.546 |
Nrbp2 | Puf60 | ENSMUSP00000019516 | ENSMUSP00000098096 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice si [...] | 0.481 |
Nrbp2 | Pycrl | ENSMUSP00000019516 | ENSMUSP00000049605 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. | 0.483 |
Nrbp2 | Rrnad1 | ENSMUSP00000019516 | ENSMUSP00000005016 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Protein RRNAD1; Belongs to the RRNAD1 family. | 0.553 |
Nrbp2 | Srfbp1 | ENSMUSP00000019516 | ENSMUSP00000025406 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. | 0.569 |
Nrbp2 | Tmem53 | ENSMUSP00000019516 | ENSMUSP00000102042 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.538 |
Nrbp2 | Tsc22d4 | ENSMUSP00000019516 | ENSMUSP00000098108 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | TSC22 domain family protein 4; Transcriptional repressor; Belongs to the TSC-22/Dip/Bun family. | 0.546 |
Nrbp2 | Ttf2 | ENSMUSP00000019516 | ENSMUSP00000076208 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | Transcription termination factor 2; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity). | 0.477 |
Puf60 | Nrbp2 | ENSMUSP00000098096 | ENSMUSP00000019516 | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice si [...] | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.481 |
Puf60 | Tmem53 | ENSMUSP00000098096 | ENSMUSP00000102042 | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice si [...] | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.409 |
Pycrl | Nrbp2 | ENSMUSP00000049605 | ENSMUSP00000019516 | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.483 |
Rrnad1 | Nrbp2 | ENSMUSP00000005016 | ENSMUSP00000019516 | Protein RRNAD1; Belongs to the RRNAD1 family. | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation. | 0.553 |
Srfbp1 | Lonp2 | ENSMUSP00000025406 | ENSMUSP00000034141 | Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. | 0.562 |