node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actn3 | Myh8 | ENSMUSP00000006626 | ENSMUSP00000019625 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Myosin-8; Muscle contraction. | 0.834 |
Actn3 | Myl1 | ENSMUSP00000006626 | ENSMUSP00000027151 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.941 |
Actn3 | Myl3 | ENSMUSP00000006626 | ENSMUSP00000078715 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.728 |
Actn3 | Myl4 | ENSMUSP00000006626 | ENSMUSP00000102570 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.640 |
Actn3 | Mylpf | ENSMUSP00000006626 | ENSMUSP00000032910 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.858 |
Actn3 | Tnnc2 | ENSMUSP00000006626 | ENSMUSP00000099384 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. | 0.939 |
Actn3 | Tnni2 | ENSMUSP00000006626 | ENSMUSP00000122733 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.937 |
Actn3 | Tnnt3 | ENSMUSP00000006626 | ENSMUSP00000136278 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.987 |
Actn3 | Tpm2 | ENSMUSP00000006626 | ENSMUSP00000103546 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Belongs to the tropomyosin family. | 0.858 |
Actn3 | Ttn | ENSMUSP00000006626 | ENSMUSP00000107477 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. | 0.824 |
Myh8 | Actn3 | ENSMUSP00000019625 | ENSMUSP00000006626 | Myosin-8; Muscle contraction. | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. | 0.834 |
Myh8 | Myl1 | ENSMUSP00000019625 | ENSMUSP00000027151 | Myosin-8; Muscle contraction. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.924 |
Myh8 | Myl3 | ENSMUSP00000019625 | ENSMUSP00000078715 | Myosin-8; Muscle contraction. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.879 |
Myh8 | Myl4 | ENSMUSP00000019625 | ENSMUSP00000102570 | Myosin-8; Muscle contraction. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.858 |
Myh8 | Mylpf | ENSMUSP00000019625 | ENSMUSP00000032910 | Myosin-8; Muscle contraction. | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.822 |
Myh8 | Tnnc2 | ENSMUSP00000019625 | ENSMUSP00000099384 | Myosin-8; Muscle contraction. | Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. | 0.909 |
Myh8 | Tnni2 | ENSMUSP00000019625 | ENSMUSP00000122733 | Myosin-8; Muscle contraction. | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.923 |
Myh8 | Tnnt3 | ENSMUSP00000019625 | ENSMUSP00000136278 | Myosin-8; Muscle contraction. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.921 |
Myh8 | Tpm2 | ENSMUSP00000019625 | ENSMUSP00000103546 | Myosin-8; Muscle contraction. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Belongs to the tropomyosin family. | 0.829 |
Myh8 | Ttn | ENSMUSP00000019625 | ENSMUSP00000107477 | Myosin-8; Muscle contraction. | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. | 0.827 |