node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyb561 | Cyb561d2 | ENSMUSP00000019734 | ENSMUSP00000044093 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.522 |
Cyb561 | Dbh | ENSMUSP00000019734 | ENSMUSP00000000910 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. | 0.558 |
Cyb561 | Frrs1 | ENSMUSP00000019734 | ENSMUSP00000143255 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. | 0.538 |
Cyb561 | Pam | ENSMUSP00000019734 | ENSMUSP00000095228 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxyl [...] | 0.580 |
Cyb561 | Pkdcc | ENSMUSP00000019734 | ENSMUSP00000129238 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Extracellular tyrosine-protein kinase PKDCC; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane. Probably plays a role in platelets: rapidl [...] | 0.460 |
Cyb561 | Slc31a1 | ENSMUSP00000019734 | ENSMUSP00000081574 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | 0.438 |
Cyb561 | Steap1 | ENSMUSP00000019734 | ENSMUSP00000015796 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.446 |
Cyb561 | Steap2 | ENSMUSP00000019734 | ENSMUSP00000111086 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.430 |
Cyb561 | Steap3 | ENSMUSP00000019734 | ENSMUSP00000108260 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP; Belongs to the STEAP family. | 0.622 |
Cyb561 | Steap4 | ENSMUSP00000019734 | ENSMUSP00000111081 | Cytochrome b561; Secretory vesicle-specific electron transport protein. | Metalloreductase STEAP4; Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthri [...] | 0.434 |
Cyb561d2 | Cyb561 | ENSMUSP00000044093 | ENSMUSP00000019734 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.522 |
Dbh | Cyb561 | ENSMUSP00000000910 | ENSMUSP00000019734 | Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.558 |
Frrs1 | Cyb561 | ENSMUSP00000143255 | ENSMUSP00000019734 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.538 |
Frrs1 | Steap2 | ENSMUSP00000143255 | ENSMUSP00000111086 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.528 |
Pam | Cyb561 | ENSMUSP00000095228 | ENSMUSP00000019734 | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxyl [...] | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.580 |
Pkdcc | Cyb561 | ENSMUSP00000129238 | ENSMUSP00000019734 | Extracellular tyrosine-protein kinase PKDCC; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane. Probably plays a role in platelets: rapidl [...] | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.460 |
Slc31a1 | Cyb561 | ENSMUSP00000081574 | ENSMUSP00000019734 | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.438 |
Slc31a1 | Steap1 | ENSMUSP00000081574 | ENSMUSP00000015796 | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.465 |
Slc31a1 | Steap2 | ENSMUSP00000081574 | ENSMUSP00000111086 | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.416 |
Steap1 | Cyb561 | ENSMUSP00000015796 | ENSMUSP00000019734 | Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | Cytochrome b561; Secretory vesicle-specific electron transport protein. | 0.446 |