node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crym | L3hypdh | ENSMUSP00000033198 | ENSMUSP00000019862 | Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.798 |
Dao | L3hypdh | ENSMUSP00000107911 | ENSMUSP00000019862 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.925 |
Fam234a | Kctd18 | ENSMUSP00000110639 | ENSMUSP00000110052 | Protein FAM234A. | Potassium channel tetramerisation domain-containing 18. | 0.568 |
Fam234a | L3hypdh | ENSMUSP00000110639 | ENSMUSP00000019862 | Protein FAM234A. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.563 |
Fam234a | Rnf122 | ENSMUSP00000110639 | ENSMUSP00000040478 | Protein FAM234A. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.537 |
Fam234a | Utp11 | ENSMUSP00000110639 | ENSMUSP00000030738 | Protein FAM234A. | Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.488 |
Hykk | L3hypdh | ENSMUSP00000039980 | ENSMUSP00000019862 | Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine; Belongs to the aminoglycoside phosphotransferase family. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.574 |
Hykk | Pycrl | ENSMUSP00000039980 | ENSMUSP00000049605 | Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine; Belongs to the aminoglycoside phosphotransferase family. | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. | 0.486 |
Kctd18 | Fam234a | ENSMUSP00000110052 | ENSMUSP00000110639 | Potassium channel tetramerisation domain-containing 18. | Protein FAM234A. | 0.568 |
Kctd18 | L3hypdh | ENSMUSP00000110052 | ENSMUSP00000019862 | Potassium channel tetramerisation domain-containing 18. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.600 |
Kctd18 | Rnf122 | ENSMUSP00000110052 | ENSMUSP00000040478 | Potassium channel tetramerisation domain-containing 18. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.421 |
Kctd18 | Utp11 | ENSMUSP00000110052 | ENSMUSP00000030738 | Potassium channel tetramerisation domain-containing 18. | Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.507 |
L3hypdh | Crym | ENSMUSP00000019862 | ENSMUSP00000033198 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). | 0.798 |
L3hypdh | Dao | ENSMUSP00000019862 | ENSMUSP00000107911 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. | 0.925 |
L3hypdh | Fam234a | ENSMUSP00000019862 | ENSMUSP00000110639 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Protein FAM234A. | 0.563 |
L3hypdh | Hykk | ENSMUSP00000019862 | ENSMUSP00000039980 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine; Belongs to the aminoglycoside phosphotransferase family. | 0.574 |
L3hypdh | Kctd18 | ENSMUSP00000019862 | ENSMUSP00000110052 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Potassium channel tetramerisation domain-containing 18. | 0.600 |
L3hypdh | Pycrl | ENSMUSP00000019862 | ENSMUSP00000049605 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. | 0.563 |
L3hypdh | Rnf122 | ENSMUSP00000019862 | ENSMUSP00000040478 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.545 |
L3hypdh | Tspo | ENSMUSP00000019862 | ENSMUSP00000037039 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism , but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis. Belongs to the TspO/BZRP family. | 0.523 |