Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ankrd39 | Ikbip | ENSMUSP00000001172 | ENSMUSP00000020149 | Ankyrin repeat domain-containing protein 39; Belongs to the ANKRD39 family. | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | 0.546 |
| Ankrd39 | Zfp617 | ENSMUSP00000001172 | ENSMUSP00000112926 | Ankyrin repeat domain-containing protein 39; Belongs to the ANKRD39 family. | Zinc finger protein 617. | 0.466 |
| Ankrd39 | Zfp747 | ENSMUSP00000001172 | ENSMUSP00000070685 | Ankyrin repeat domain-containing protein 39; Belongs to the ANKRD39 family. | Zinc finger protein 747. | 0.754 |
| Elp1 | Ikbip | ENSMUSP00000030140 | ENSMUSP00000020149 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | 0.447 |
| Elp1 | Ikbkb | ENSMUSP00000030140 | ENSMUSP00000033939 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.532 |
| Elp1 | Irak1 | ENSMUSP00000030140 | ENSMUSP00000033769 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquit [...] | 0.463 |
| Elp1 | Nfkbib | ENSMUSP00000030140 | ENSMUSP00000032815 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.527 |
| Ikbip | Ankrd39 | ENSMUSP00000020149 | ENSMUSP00000001172 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Ankyrin repeat domain-containing protein 39; Belongs to the ANKRD39 family. | 0.546 |
| Ikbip | Elp1 | ENSMUSP00000020149 | ENSMUSP00000030140 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | 0.447 |
| Ikbip | Ikbkb | ENSMUSP00000020149 | ENSMUSP00000033939 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | 0.586 |
| Ikbip | Insyn2b | ENSMUSP00000020149 | ENSMUSP00000129183 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | INSYN2B protein; Belongs to the INSYN2 family. | 0.441 |
| Ikbip | Irak1 | ENSMUSP00000020149 | ENSMUSP00000033769 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquit [...] | 0.471 |
| Ikbip | L3hypdh | ENSMUSP00000020149 | ENSMUSP00000019862 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.471 |
| Ikbip | Nfkbib | ENSMUSP00000020149 | ENSMUSP00000032815 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. | 0.456 |
| Ikbip | Olfml2b | ENSMUSP00000020149 | ENSMUSP00000047291 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Olfactomedin-like protein 2B. | 0.478 |
| Ikbip | Zfp617 | ENSMUSP00000020149 | ENSMUSP00000112926 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Zinc finger protein 617. | 0.412 |
| Ikbip | Zfp747 | ENSMUSP00000020149 | ENSMUSP00000070685 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Zinc finger protein 747. | 0.499 |
| Ikbkb | Elp1 | ENSMUSP00000033939 | ENSMUSP00000030140 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] | 0.532 |
| Ikbkb | Ikbip | ENSMUSP00000033939 | ENSMUSP00000020149 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | 0.586 |
| Ikbkb | Irak1 | ENSMUSP00000033939 | ENSMUSP00000033769 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquit [...] | 0.842 |
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