node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc47 | Ncln | ENSMUSP00000002043 | ENSMUSP00000020463 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.905 |
Ccdc47 | Rpl19 | ENSMUSP00000002043 | ENSMUSP00000017548 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 60S ribosomal protein L19. | 0.665 |
Ccdc47 | Rpl4 | ENSMUSP00000002043 | ENSMUSP00000034966 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.671 |
Ccdc47 | Sec61a1 | ENSMUSP00000002043 | ENSMUSP00000032168 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] | 0.703 |
Ccdc47 | Sec61a2 | ENSMUSP00000002043 | ENSMUSP00000100046 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.776 |
Ccdc47 | Tmco1 | ENSMUSP00000002043 | ENSMUSP00000142042 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.953 |
Ccdc47 | Tmem147 | ENSMUSP00000002043 | ENSMUSP00000006478 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.908 |
Dennd3 | Ncln | ENSMUSP00000046774 | ENSMUSP00000020463 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the [...] | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.748 |
Dennd3 | Tbata | ENSMUSP00000046774 | ENSMUSP00000036422 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the [...] | Protein TBATA; Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway; Belongs to the TBATA family. | 0.703 |
Ncln | Ccdc47 | ENSMUSP00000020463 | ENSMUSP00000002043 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis. | 0.905 |
Ncln | Dennd3 | ENSMUSP00000020463 | ENSMUSP00000046774 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the [...] | 0.748 |
Ncln | Nomo1 | ENSMUSP00000020463 | ENSMUSP00000033121 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Nodal modulator 1; May antagonize Nodal signaling. | 0.839 |
Ncln | Rpl19 | ENSMUSP00000020463 | ENSMUSP00000017548 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 60S ribosomal protein L19. | 0.725 |
Ncln | Rpl4 | ENSMUSP00000020463 | ENSMUSP00000034966 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. | 0.725 |
Ncln | Sec61a1 | ENSMUSP00000020463 | ENSMUSP00000032168 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] | 0.709 |
Ncln | Sec61a2 | ENSMUSP00000020463 | ENSMUSP00000100046 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). | 0.771 |
Ncln | Tbata | ENSMUSP00000020463 | ENSMUSP00000036422 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Protein TBATA; Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway; Belongs to the TBATA family. | 0.822 |
Ncln | Tmco1 | ENSMUSP00000020463 | ENSMUSP00000142042 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.876 |
Ncln | Tmem147 | ENSMUSP00000020463 | ENSMUSP00000006478 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). | 0.933 |
Nomo1 | Ncln | ENSMUSP00000033121 | ENSMUSP00000020463 | Nodal modulator 1; May antagonize Nodal signaling. | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. | 0.839 |