node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | Cfb | ENSMUSP00000024988 | ENSMUSP00000025229 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.992 |
C3 | Gzmm | ENSMUSP00000024988 | ENSMUSP00000020549 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | 0.456 |
Ccnjl | Gzmm | ENSMUSP00000058111 | ENSMUSP00000020549 | Cyclin-J-like protein; Belongs to the cyclin family. Cyclin J subfamily. | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | 0.528 |
Cfb | C3 | ENSMUSP00000025229 | ENSMUSP00000024988 | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.992 |
Cfb | Gzmm | ENSMUSP00000025229 | ENSMUSP00000020549 | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | 0.488 |
Ctsc | Gzmm | ENSMUSP00000032779 | ENSMUSP00000020549 | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family. | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | 0.622 |
Ctsc | Prf1 | ENSMUSP00000032779 | ENSMUSP00000151354 | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. | 0.598 |
Ctsc | Serpinb9 | ENSMUSP00000032779 | ENSMUSP00000099002 | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9; Belongs to the serpin family. | 0.588 |
Ctsw | Gzmm | ENSMUSP00000025844 | ENSMUSP00000020549 | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | 0.464 |
Ctsw | Nkg7 | ENSMUSP00000025844 | ENSMUSP00000068946 | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. | Protein NKG7. | 0.850 |
Ctsw | Prf1 | ENSMUSP00000025844 | ENSMUSP00000151354 | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. | 0.623 |
Gzmm | C3 | ENSMUSP00000020549 | ENSMUSP00000024988 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. | 0.456 |
Gzmm | Ccnjl | ENSMUSP00000020549 | ENSMUSP00000058111 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Cyclin-J-like protein; Belongs to the cyclin family. Cyclin J subfamily. | 0.528 |
Gzmm | Cfb | ENSMUSP00000020549 | ENSMUSP00000025229 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | 0.488 |
Gzmm | Ctsc | ENSMUSP00000020549 | ENSMUSP00000032779 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family. | 0.622 |
Gzmm | Ctsw | ENSMUSP00000020549 | ENSMUSP00000025844 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family. | 0.464 |
Gzmm | Lag3 | ENSMUSP00000020549 | ENSMUSP00000032217 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] | 0.456 |
Gzmm | Nkg7 | ENSMUSP00000020549 | ENSMUSP00000068946 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Protein NKG7. | 0.572 |
Gzmm | Prf1 | ENSMUSP00000020549 | ENSMUSP00000151354 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. | 0.631 |
Gzmm | Rd3l | ENSMUSP00000020549 | ENSMUSP00000140454 | Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family. | Retinal degeneration 3-like. | 0.576 |