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STRINGSTRING
Mpo protein (mouse) - STRING interaction network
"Mpo" - Myeloperoxidase in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MpoMyeloperoxidase; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily (718 aa)    
Predicted Functional Partners:
Elane
Neutrophil elastase; Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity) (265 aa)
     
  0.993
Ctsg
Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis (261 aa)
     
  0.991
Bpi
Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family (486 aa)
     
 
  0.959
Lyz2
Lysozyme C-2; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram- positive bacteria; Belongs to the glycosyl hydrolase 22 family (148 aa)
     
 
  0.948
Try4
Trypsin 4; Belongs to the peptidase S1 family (246 aa)
       
  0.948
Serpina3a
Serine (or cysteine) peptidase inhibitor, clade A, member 3A; Belongs to the serpin family (452 aa)
         
  0.947
Serpina3b
Serine (or cysteine) peptidase inhibitor, clade A, member 3B (420 aa)
         
  0.946
Serpina3f
Serine (or cysteine) peptidase inhibitor, clade A, member 3F; Belongs to the serpin family (445 aa)
         
  0.946
Serpina3i
Serine (or cysteine) peptidase inhibitor, clade A, member 3I; Belongs to the serpin family (408 aa)
         
  0.946
Serpina3m
Serine (or cysteine) peptidase inhibitor, clade A, member 3M; Belongs to the serpin family (418 aa)
         
  0.946
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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