| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Eed | Hs1bp3 | ENSMUSP00000102853 | ENSMUSP00000020927 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...] | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.488 |
| Eed | Snx18 | ENSMUSP00000102853 | ENSMUSP00000104864 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...] | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | 0.488 |
| Gdf7 | Hs1bp3 | ENSMUSP00000038301 | ENSMUSP00000020927 | Growth/differentiation factor 7. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.441 |
| Gdf7 | Ldah | ENSMUSP00000038301 | ENSMUSP00000042285 | Growth/differentiation factor 7. | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | 0.443 |
| Hcls1 | Hs1bp3 | ENSMUSP00000023531 | ENSMUSP00000020927 | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.706 |
| Hs1bp3 | Eed | ENSMUSP00000020927 | ENSMUSP00000102853 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...] | 0.488 |
| Hs1bp3 | Gdf7 | ENSMUSP00000020927 | ENSMUSP00000038301 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Growth/differentiation factor 7. | 0.441 |
| Hs1bp3 | Hcls1 | ENSMUSP00000020927 | ENSMUSP00000023531 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). | 0.706 |
| Hs1bp3 | Ldah | ENSMUSP00000020927 | ENSMUSP00000042285 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | 0.679 |
| Hs1bp3 | Lingo4 | ENSMUSP00000020927 | ENSMUSP00000058050 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4. | 0.450 |
| Hs1bp3 | Mtmr3 | ENSMUSP00000020927 | ENSMUSP00000105569 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.433 |
| Hs1bp3 | Scoc | ENSMUSP00000020927 | ENSMUSP00000080221 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | 0.439 |
| Hs1bp3 | Snx10 | ENSMUSP00000020927 | ENSMUSP00000044165 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. | 0.434 |
| Hs1bp3 | Snx18 | ENSMUSP00000020927 | ENSMUSP00000104864 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | 0.447 |
| Hs1bp3 | Tor2a | ENSMUSP00000020927 | ENSMUSP00000009707 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Torsin-2A; Belongs to the ClpA/ClpB family. Torsin subfamily. | 0.506 |
| Ldah | Gdf7 | ENSMUSP00000042285 | ENSMUSP00000038301 | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | Growth/differentiation factor 7. | 0.443 |
| Ldah | Hs1bp3 | ENSMUSP00000042285 | ENSMUSP00000020927 | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.679 |
| Lingo4 | Hs1bp3 | ENSMUSP00000058050 | ENSMUSP00000020927 | Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.450 |
| Mtmr3 | Hs1bp3 | ENSMUSP00000105569 | ENSMUSP00000020927 | Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.433 |
| Scoc | Hs1bp3 | ENSMUSP00000080221 | ENSMUSP00000020927 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.439 |
