node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ctns | Hs1bp3 | ENSMUSP00000104116 | ENSMUSP00000020927 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.567 |
Gdf7 | Hs1bp3 | ENSMUSP00000038301 | ENSMUSP00000020927 | Growth/differentiation factor 7. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.452 |
Hcls1 | Hs1bp3 | ENSMUSP00000023531 | ENSMUSP00000020927 | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.515 |
Hs1bp3 | Ctns | ENSMUSP00000020927 | ENSMUSP00000104116 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family. | 0.567 |
Hs1bp3 | Gdf7 | ENSMUSP00000020927 | ENSMUSP00000038301 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Growth/differentiation factor 7. | 0.452 |
Hs1bp3 | Hcls1 | ENSMUSP00000020927 | ENSMUSP00000023531 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). | 0.515 |
Hs1bp3 | Ldah | ENSMUSP00000020927 | ENSMUSP00000042285 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | 0.560 |
Hs1bp3 | Lingo4 | ENSMUSP00000020927 | ENSMUSP00000058050 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4. | 0.520 |
Hs1bp3 | Nkain3 | ENSMUSP00000020927 | ENSMUSP00000113113 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Belongs to the NKAIN family. | 0.676 |
Hs1bp3 | Snx10 | ENSMUSP00000020927 | ENSMUSP00000044165 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. | 0.536 |
Hs1bp3 | Snx18 | ENSMUSP00000020927 | ENSMUSP00000104864 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | 0.449 |
Hs1bp3 | Tbc1d14 | ENSMUSP00000020927 | ENSMUSP00000117414 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. | 0.425 |
Hs1bp3 | Tor2a | ENSMUSP00000020927 | ENSMUSP00000009707 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | Torsin-2A; Belongs to the ClpA/ClpB family. Torsin subfamily. | 0.480 |
Ldah | Hs1bp3 | ENSMUSP00000042285 | ENSMUSP00000020927 | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.560 |
Lingo4 | Hs1bp3 | ENSMUSP00000058050 | ENSMUSP00000020927 | Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.520 |
Nkain3 | Hs1bp3 | ENSMUSP00000113113 | ENSMUSP00000020927 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Belongs to the NKAIN family. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.676 |
Snx10 | Hs1bp3 | ENSMUSP00000044165 | ENSMUSP00000020927 | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.536 |
Snx18 | Hs1bp3 | ENSMUSP00000104864 | ENSMUSP00000020927 | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.449 |
Snx18 | Tbc1d14 | ENSMUSP00000104864 | ENSMUSP00000117414 | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. | 0.512 |
Tbc1d14 | Hs1bp3 | ENSMUSP00000117414 | ENSMUSP00000020927 | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. | HCLS1-binding protein 3; May be a modulator of IL-2 signaling. | 0.425 |