node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef38 | Sh3yl1 | ENSMUSP00000124280 | ENSMUSP00000020997 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor. | SH3 domain-containing YSC84-like protein 1. | 0.545 |
Efcab10 | Nt5c1b | ENSMUSP00000020878 | ENSMUSP00000002456 | EF-hand calcium-binding domain-containing protein 10. | Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. | 0.746 |
Efcab10 | Sh3yl1 | ENSMUSP00000020878 | ENSMUSP00000020997 | EF-hand calcium-binding domain-containing protein 10. | SH3 domain-containing YSC84-like protein 1. | 0.658 |
Fam110c | Sh3yl1 | ENSMUSP00000041563 | ENSMUSP00000020997 | Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. | SH3 domain-containing YSC84-like protein 1. | 0.524 |
Mvk | Sh3yl1 | ENSMUSP00000107858 | ENSMUSP00000020997 | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | SH3 domain-containing YSC84-like protein 1. | 0.776 |
Nbr1 | Sh3yl1 | ENSMUSP00000099388 | ENSMUSP00000020997 | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. | SH3 domain-containing YSC84-like protein 1. | 0.533 |
Nt5c1b | Efcab10 | ENSMUSP00000002456 | ENSMUSP00000020878 | Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. | EF-hand calcium-binding domain-containing protein 10. | 0.746 |
Nt5c1b | Sh3yl1 | ENSMUSP00000002456 | ENSMUSP00000020997 | Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. | SH3 domain-containing YSC84-like protein 1. | 0.542 |
Sh3d19 | Sh3yl1 | ENSMUSP00000158775 | ENSMUSP00000020997 | SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). | SH3 domain-containing YSC84-like protein 1. | 0.676 |
Sh3yl1 | Arhgef38 | ENSMUSP00000020997 | ENSMUSP00000124280 | SH3 domain-containing YSC84-like protein 1. | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor. | 0.545 |
Sh3yl1 | Efcab10 | ENSMUSP00000020997 | ENSMUSP00000020878 | SH3 domain-containing YSC84-like protein 1. | EF-hand calcium-binding domain-containing protein 10. | 0.658 |
Sh3yl1 | Fam110c | ENSMUSP00000020997 | ENSMUSP00000041563 | SH3 domain-containing YSC84-like protein 1. | Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. | 0.524 |
Sh3yl1 | Mvk | ENSMUSP00000020997 | ENSMUSP00000107858 | SH3 domain-containing YSC84-like protein 1. | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.776 |
Sh3yl1 | Nbr1 | ENSMUSP00000020997 | ENSMUSP00000099388 | SH3 domain-containing YSC84-like protein 1. | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. | 0.533 |
Sh3yl1 | Nt5c1b | ENSMUSP00000020997 | ENSMUSP00000002456 | SH3 domain-containing YSC84-like protein 1. | Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. | 0.542 |
Sh3yl1 | Sh3d19 | ENSMUSP00000020997 | ENSMUSP00000158775 | SH3 domain-containing YSC84-like protein 1. | SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). | 0.676 |
Sh3yl1 | Smap2 | ENSMUSP00000020997 | ENSMUSP00000035800 | SH3 domain-containing YSC84-like protein 1. | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network. | 0.616 |
Sh3yl1 | Was | ENSMUSP00000020997 | ENSMUSP00000033505 | SH3 domain-containing YSC84-like protein 1. | Wiskott-Aldrich syndrome protein homolog; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombinatio [...] | 0.818 |
Sh3yl1 | Wasl | ENSMUSP00000020997 | ENSMUSP00000031695 | SH3 domain-containing YSC84-like protein 1. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.791 |
Smap2 | Sh3yl1 | ENSMUSP00000035800 | ENSMUSP00000020997 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network. | SH3 domain-containing YSC84-like protein 1. | 0.616 |