node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Coasy | Dcakd | ENSMUSP00000102929 | ENSMUSP00000021313 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | 0.723 |
Coasy | Gart | ENSMUSP00000102929 | ENSMUSP00000023684 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.689 |
Coasy | Neil3 | ENSMUSP00000102929 | ENSMUSP00000041909 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | Endonuclease 8-like 3; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and G [...] | 0.778 |
Coasy | Ppcdc | ENSMUSP00000102929 | ENSMUSP00000082856 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine (By similarity). | 0.983 |
Coasy | Ppcs | ENSMUSP00000102929 | ENSMUSP00000030385 | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | Phosphopantothenate--cysteine ligase; Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate. | 0.875 |
Dcakd | Coasy | ENSMUSP00000021313 | ENSMUSP00000102929 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | 0.723 |
Dcakd | Gart | ENSMUSP00000021313 | ENSMUSP00000023684 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.683 |
Dcakd | Hexim2 | ENSMUSP00000021313 | ENSMUSP00000053678 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity); Belongs to the HEXIM family. | 0.689 |
Dcakd | Neil3 | ENSMUSP00000021313 | ENSMUSP00000041909 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Endonuclease 8-like 3; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and G [...] | 0.780 |
Dcakd | Nmt1 | ENSMUSP00000021313 | ENSMUSP00000021314 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis. | 0.779 |
Dcakd | Ppcdc | ENSMUSP00000021313 | ENSMUSP00000082856 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine (By similarity). | 0.654 |
Dcakd | Ppcs | ENSMUSP00000021313 | ENSMUSP00000030385 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Phosphopantothenate--cysteine ligase; Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate. | 0.686 |
Dcakd | Rundc3a | ENSMUSP00000021313 | ENSMUSP00000006750 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family. | 0.661 |
Dcakd | Slc25a39 | ENSMUSP00000021313 | ENSMUSP00000018821 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.630 |
Dcakd | Tmub2 | ENSMUSP00000021313 | ENSMUSP00000116327 | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | Transmembrane and ubiquitin-like domain-containing protein 2. | 0.663 |
Gart | Coasy | ENSMUSP00000023684 | ENSMUSP00000102929 | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family. | 0.689 |
Gart | Dcakd | ENSMUSP00000023684 | ENSMUSP00000021313 | Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | 0.683 |
Hexim2 | Dcakd | ENSMUSP00000053678 | ENSMUSP00000021313 | Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity); Belongs to the HEXIM family. | Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family. | 0.689 |
Hexim2 | Nmt1 | ENSMUSP00000053678 | ENSMUSP00000021314 | Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity); Belongs to the HEXIM family. | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis. | 0.638 |
Hexim2 | Rundc3a | ENSMUSP00000053678 | ENSMUSP00000006750 | Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity); Belongs to the HEXIM family. | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family. | 0.623 |