node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anks1 | Fance | ENSMUSP00000025058 | ENSMUSP00000110451 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | Fanconi anemia, complementation group E. | 0.545 |
Anks1 | Gcc2 | ENSMUSP00000025058 | ENSMUSP00000054033 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | 0.493 |
Anks1 | Pi15 | ENSMUSP00000025058 | ENSMUSP00000085826 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.492 |
Anks1 | Slc25a29 | ENSMUSP00000025058 | ENSMUSP00000021693 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.513 |
Arg1 | Slc25a29 | ENSMUSP00000020161 | ENSMUSP00000021693 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.512 |
Begain | Slc25a29 | ENSMUSP00000140393 | ENSMUSP00000021693 | Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD). | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.696 |
Begain | Wdr25 | ENSMUSP00000140393 | ENSMUSP00000035553 | Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD). | WD repeat-containing protein 25. | 0.808 |
Fance | Anks1 | ENSMUSP00000110451 | ENSMUSP00000025058 | Fanconi anemia, complementation group E. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | 0.545 |
Fance | Gcc2 | ENSMUSP00000110451 | ENSMUSP00000054033 | Fanconi anemia, complementation group E. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | 0.466 |
Fance | Pi15 | ENSMUSP00000110451 | ENSMUSP00000085826 | Fanconi anemia, complementation group E. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.421 |
Fance | Slc25a29 | ENSMUSP00000110451 | ENSMUSP00000021693 | Fanconi anemia, complementation group E. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.512 |
Gcc2 | Anks1 | ENSMUSP00000054033 | ENSMUSP00000025058 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | 0.493 |
Gcc2 | Fance | ENSMUSP00000054033 | ENSMUSP00000110451 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | Fanconi anemia, complementation group E. | 0.466 |
Gcc2 | Pi15 | ENSMUSP00000054033 | ENSMUSP00000085826 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.463 |
Gcc2 | Slc25a29 | ENSMUSP00000054033 | ENSMUSP00000021693 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.517 |
Mrps21 | Slc25a29 | ENSMUSP00000066990 | ENSMUSP00000021693 | 28S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.545 |
Pi15 | Anks1 | ENSMUSP00000085826 | ENSMUSP00000025058 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. | 0.492 |
Pi15 | Fance | ENSMUSP00000085826 | ENSMUSP00000110451 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Fanconi anemia, complementation group E. | 0.421 |
Pi15 | Gcc2 | ENSMUSP00000085826 | ENSMUSP00000054033 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity). | 0.463 |
Pi15 | Slc25a29 | ENSMUSP00000085826 | ENSMUSP00000021693 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.519 |