node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gpr107 | Gpr137b | ENSMUSP00000056739 | ENSMUSP00000021738 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | 0.547 |
Gpr107 | Gpr152 | ENSMUSP00000056739 | ENSMUSP00000094062 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.404 |
Gpr107 | Gprc5c | ENSMUSP00000056739 | ENSMUSP00000061760 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways. | 0.408 |
Gpr107 | Tmem181a | ENSMUSP00000056739 | ENSMUSP00000086333 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Transmembrane protein 181A. | 0.437 |
Gpr107 | Tmem185a | ENSMUSP00000056739 | ENSMUSP00000099043 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Transmembrane protein 185A. | 0.530 |
Gpr108 | Gpr137b | ENSMUSP00000156910 | ENSMUSP00000021738 | Protein GPR108; Belongs to the LU7TM family. | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | 0.559 |
Gpr108 | Gpr149 | ENSMUSP00000156910 | ENSMUSP00000060893 | Protein GPR108; Belongs to the LU7TM family. | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.430 |
Gpr108 | Gpr152 | ENSMUSP00000156910 | ENSMUSP00000094062 | Protein GPR108; Belongs to the LU7TM family. | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.648 |
Gpr108 | Gpr82 | ENSMUSP00000156910 | ENSMUSP00000062535 | Protein GPR108; Belongs to the LU7TM family. | Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.405 |
Gpr108 | Gprc5c | ENSMUSP00000156910 | ENSMUSP00000061760 | Protein GPR108; Belongs to the LU7TM family. | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways. | 0.426 |
Gpr108 | Tmem181a | ENSMUSP00000156910 | ENSMUSP00000086333 | Protein GPR108; Belongs to the LU7TM family. | Transmembrane protein 181A. | 0.435 |
Gpr108 | Tmem185a | ENSMUSP00000156910 | ENSMUSP00000099043 | Protein GPR108; Belongs to the LU7TM family. | Transmembrane protein 185A. | 0.523 |
Gpr137b | Gpr107 | ENSMUSP00000021738 | ENSMUSP00000056739 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.547 |
Gpr137b | Gpr108 | ENSMUSP00000021738 | ENSMUSP00000156910 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Protein GPR108; Belongs to the LU7TM family. | 0.559 |
Gpr137b | Gpr149 | ENSMUSP00000021738 | ENSMUSP00000060893 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.411 |
Gpr137b | Gpr152 | ENSMUSP00000021738 | ENSMUSP00000094062 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.470 |
Gpr137b | Gpr155 | ENSMUSP00000021738 | ENSMUSP00000075788 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | G protein-coupled receptor 155. | 0.532 |
Gpr137b | Gpr82 | ENSMUSP00000021738 | ENSMUSP00000062535 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.430 |
Gpr137b | Gprc5c | ENSMUSP00000021738 | ENSMUSP00000061760 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways. | 0.459 |
Gpr137b | Tm7sf3 | ENSMUSP00000021738 | ENSMUSP00000045650 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR). | 0.486 |