STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prl4a1Prolactin-4A1. (227 aa)    
Predicted Functional Partners:
Prl8a2
Prolactin family 8, subfamily a, member 2.
   
  
0.746
Tpbpa
Trophoblast-specific protein alpha; It may be a growth factor/hormone, perhaps involved in interaction between the maternal and fetal systems in maintenance of pregnancy.
   
  
 0.728
Prl8a1
Prolactin family 8, subfamily a, member 1.
  
  
0.691
Prl7d1
Prolactin-7D1; Belongs to the somatotropin/prolactin family.
  
  
0.644
Prl7a1
Prolactin-7A1; Belongs to the somatotropin/prolactin family.
  
  
0.634
Prl2b1
Prolactin-2B1; Belongs to the somatotropin/prolactin family.
  
  
0.633
Fshb
Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family.
   
  
 0.619
Prl2a1
Prolactin-2A1; Belongs to the somatotropin/prolactin family.
  
  
0.616
Cyp11a1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
  
 0.575
Ctsq
Cathepsin Q; Belongs to the peptidase C1 family.
   
  
 0.550
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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