node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccl17 | Ccl26 | ENSMUSP00000034232 | ENSMUSP00000091779 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | Chemokine (C-C motif) ligand 26. | 0.989 |
Ccl17 | Ccl5 | ENSMUSP00000034232 | ENSMUSP00000039600 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.999 |
Ccl17 | Cxcl10 | ENSMUSP00000034232 | ENSMUSP00000047646 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C- dependent pathway, an increa [...] | 0.885 |
Ccl17 | Cxcl12 | ENSMUSP00000034232 | ENSMUSP00000072800 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migrat [...] | 0.719 |
Ccl17 | Cxcl14 | ENSMUSP00000034232 | ENSMUSP00000021970 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 14; Chemotactic for CESS B-cells and THP-1 monocytes, but not T- cells. | 0.966 |
Ccl17 | Cxcl17 | ENSMUSP00000034232 | ENSMUSP00000144096 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C- X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions; Belongs to the intercrine alpha (chemokine CxC) family. | 0.965 |
Ccl17 | Cxcl5 | ENSMUSP00000034232 | ENSMUSP00000031318 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 5; May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. | 0.813 |
Ccl17 | Cxcl9 | ENSMUSP00000034232 | ENSMUSP00000108716 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 9; May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. | 0.804 |
Ccl17 | Cxcr4 | ENSMUSP00000034232 | ENSMUSP00000053489 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Invo [...] | 0.890 |
Ccl17 | Ppbp | ENSMUSP00000034232 | ENSMUSP00000031319 | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | Chemokine subfamily B Cys-X-Cys. | 0.513 |
Ccl26 | Ccl17 | ENSMUSP00000091779 | ENSMUSP00000034232 | Chemokine (C-C motif) ligand 26. | C-C motif chemokine; Belongs to the intercrine beta (chemokine CC) family. | 0.989 |
Ccl26 | Ccl5 | ENSMUSP00000091779 | ENSMUSP00000039600 | Chemokine (C-C motif) ligand 26. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.997 |
Ccl26 | Cxcl10 | ENSMUSP00000091779 | ENSMUSP00000047646 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C- dependent pathway, an increa [...] | 0.984 |
Ccl26 | Cxcl12 | ENSMUSP00000091779 | ENSMUSP00000072800 | Chemokine (C-C motif) ligand 26. | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migrat [...] | 0.966 |
Ccl26 | Cxcl14 | ENSMUSP00000091779 | ENSMUSP00000021970 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 14; Chemotactic for CESS B-cells and THP-1 monocytes, but not T- cells. | 0.962 |
Ccl26 | Cxcl17 | ENSMUSP00000091779 | ENSMUSP00000144096 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C- X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions; Belongs to the intercrine alpha (chemokine CxC) family. | 0.962 |
Ccl26 | Cxcl5 | ENSMUSP00000091779 | ENSMUSP00000031318 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 5; May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation. | 0.823 |
Ccl26 | Cxcl9 | ENSMUSP00000091779 | ENSMUSP00000108716 | Chemokine (C-C motif) ligand 26. | C-X-C motif chemokine 9; May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. | 0.969 |
Ccl26 | Cxcr4 | ENSMUSP00000091779 | ENSMUSP00000053489 | Chemokine (C-C motif) ligand 26. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Invo [...] | 0.725 |
Ccl26 | Ppbp | ENSMUSP00000091779 | ENSMUSP00000031319 | Chemokine (C-C motif) ligand 26. | Chemokine subfamily B Cys-X-Cys. | 0.958 |