node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1810009J06Rik | F2rl2 | ENSMUSP00000075935 | ENSMUSP00000022182 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.655 |
1810009J06Rik | F2rl3 | ENSMUSP00000075935 | ENSMUSP00000054426 | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.650 |
2210010C04Rik | F2rl2 | ENSMUSP00000031931 | ENSMUSP00000022182 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.650 |
2210010C04Rik | F2rl3 | ENSMUSP00000031931 | ENSMUSP00000054426 | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.650 |
Ctsg | F2rl2 | ENSMUSP00000015583 | ENSMUSP00000022182 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.669 |
Ctsg | F2rl3 | ENSMUSP00000015583 | ENSMUSP00000054426 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.744 |
Ctsg | Gm5771 | ENSMUSP00000015583 | ENSMUSP00000039684 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Predicted gene, EG436523; Belongs to the peptidase S1 family. | 0.487 |
Ctsg | Plg | ENSMUSP00000015583 | ENSMUSP00000014578 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.474 |
Ctsg | Prss1 | ENSMUSP00000015583 | ENSMUSP00000031910 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Protease, serine, 1 (Trypsin 1); Belongs to the peptidase S1 family. | 0.483 |
Ctsg | Try4 | ENSMUSP00000015583 | ENSMUSP00000031913 | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | Pancreatic trypsin; Belongs to the peptidase S1 family. | 0.490 |
F2 | F2rl2 | ENSMUSP00000028681 | ENSMUSP00000022182 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.995 |
F2 | F2rl3 | ENSMUSP00000028681 | ENSMUSP00000054426 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.996 |
F2 | Plg | ENSMUSP00000028681 | ENSMUSP00000014578 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.977 |
F2rl2 | 1810009J06Rik | ENSMUSP00000022182 | ENSMUSP00000075935 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family. | 0.655 |
F2rl2 | 2210010C04Rik | ENSMUSP00000022182 | ENSMUSP00000031931 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family. | 0.650 |
F2rl2 | Ctsg | ENSMUSP00000022182 | ENSMUSP00000015583 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | Cathepsin G; This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movement and mitosis. | 0.669 |
F2rl2 | F2 | ENSMUSP00000022182 | ENSMUSP00000028681 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.995 |
F2rl2 | F2rl3 | ENSMUSP00000022182 | ENSMUSP00000054426 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | 0.916 |
F2rl2 | Gm5771 | ENSMUSP00000022182 | ENSMUSP00000039684 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | Predicted gene, EG436523; Belongs to the peptidase S1 family. | 0.650 |
F2rl2 | Gzma | ENSMUSP00000022182 | ENSMUSP00000023897 | Proteinase-activated receptor 3; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family. | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). | 0.652 |