node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acaa1a | Acaa1b | ENSMUSP00000042351 | ENSMUSP00000010795 | 3-ketoacyl-CoA thiolase A, peroxisomal. | 3-ketoacyl-CoA thiolase B, peroxisomal. | 0.919 |
Acaa1a | Acox1 | ENSMUSP00000042351 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.991 |
Acaa1a | Acox2 | ENSMUSP00000042351 | ENSMUSP00000126464 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.853 |
Acaa1a | Acox3 | ENSMUSP00000042351 | ENSMUSP00000063412 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. | 0.973 |
Acaa1a | Amacr | ENSMUSP00000042351 | ENSMUSP00000066915 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Alpha-methylacyl-CoA racemase; Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (By similarity). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3- methyl-branched nor linear-chain acyl-CoAs (By similarity). Belongs to the CoA-transferase I [...] | 0.564 |
Acaa1a | Eci2 | ENSMUSP00000042351 | ENSMUSP00000131735 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). | 0.931 |
Acaa1a | Eci3 | ENSMUSP00000042351 | ENSMUSP00000021853 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Enoyl-CoA delta isomerase 3, peroxisomal; Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA. May also have activity towards other enoyl-CoA species (Probable). | 0.857 |
Acaa1a | Hadhb | ENSMUSP00000042351 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.527 |
Acaa1a | Hsd17b4 | ENSMUSP00000042351 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.980 |
Acaa1b | Acaa1a | ENSMUSP00000010795 | ENSMUSP00000042351 | 3-ketoacyl-CoA thiolase B, peroxisomal. | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.919 |
Acaa1b | Acox1 | ENSMUSP00000010795 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.987 |
Acaa1b | Acox2 | ENSMUSP00000010795 | ENSMUSP00000126464 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity). | 0.833 |
Acaa1b | Acox3 | ENSMUSP00000010795 | ENSMUSP00000063412 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. | 0.972 |
Acaa1b | Amacr | ENSMUSP00000010795 | ENSMUSP00000066915 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Alpha-methylacyl-CoA racemase; Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (By similarity). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3- methyl-branched nor linear-chain acyl-CoAs (By similarity). Belongs to the CoA-transferase I [...] | 0.534 |
Acaa1b | Eci2 | ENSMUSP00000010795 | ENSMUSP00000131735 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). | 0.918 |
Acaa1b | Eci3 | ENSMUSP00000010795 | ENSMUSP00000021853 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Enoyl-CoA delta isomerase 3, peroxisomal; Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA. May also have activity towards other enoyl-CoA species (Probable). | 0.865 |
Acaa1b | Hadhb | ENSMUSP00000010795 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.512 |
Acaa1b | Hsd17b4 | ENSMUSP00000010795 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.971 |
Acaa1b | Slc27a5 | ENSMUSP00000010795 | ENSMUSP00000032539 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Catalyzes the activation of the primary bile acid, cholic acid. Both primary bile acid (chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (By similarity). In [...] | 0.424 |
Acox1 | Acaa1a | ENSMUSP00000063325 | ENSMUSP00000042351 | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.991 |