node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfap47 | Dpy30 | ENSMUSP00000142707 | ENSMUSP00000126702 | Cilia and flagella-associated protein 47. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | 0.436 |
Cfap47 | Dydc1 | ENSMUSP00000142707 | ENSMUSP00000139412 | Cilia and flagella-associated protein 47. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.588 |
Cfap47 | Lrrc43 | ENSMUSP00000142707 | ENSMUSP00000091885 | Cilia and flagella-associated protein 47. | Leucine-rich repeat-containing protein 43. | 0.734 |
Cfap47 | Spag17 | ENSMUSP00000142707 | ENSMUSP00000134066 | Cilia and flagella-associated protein 47. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.473 |
Cfap47 | Tex43 | ENSMUSP00000142707 | ENSMUSP00000038152 | Cilia and flagella-associated protein 47. | Testis-expressed protein 43. | 0.644 |
Dpy30 | Cfap47 | ENSMUSP00000126702 | ENSMUSP00000142707 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | Cilia and flagella-associated protein 47. | 0.436 |
Dpy30 | Dydc1 | ENSMUSP00000126702 | ENSMUSP00000139412 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.747 |
Dpy30 | Dydc2 | ENSMUSP00000126702 | ENSMUSP00000022316 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | DPY30 domain-containing 2. | 0.621 |
Dpy30 | Setd1a | ENSMUSP00000126702 | ENSMUSP00000047672 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.986 |
Dpy30 | Setd1b | ENSMUSP00000126702 | ENSMUSP00000133933 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.997 |
Dpy30 | Spag17 | ENSMUSP00000126702 | ENSMUSP00000134066 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.706 |
Dydc1 | Cfap47 | ENSMUSP00000139412 | ENSMUSP00000142707 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Cilia and flagella-associated protein 47. | 0.588 |
Dydc1 | Dpy30 | ENSMUSP00000139412 | ENSMUSP00000126702 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] | 0.747 |
Dydc1 | Dydc2 | ENSMUSP00000139412 | ENSMUSP00000022316 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | DPY30 domain-containing 2. | 0.734 |
Dydc1 | Lrrc43 | ENSMUSP00000139412 | ENSMUSP00000091885 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Leucine-rich repeat-containing protein 43. | 0.733 |
Dydc1 | Setd1a | ENSMUSP00000139412 | ENSMUSP00000047672 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.570 |
Dydc1 | Setd1b | ENSMUSP00000139412 | ENSMUSP00000133933 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.570 |
Dydc1 | Sh2d4b | ENSMUSP00000139412 | ENSMUSP00000093699 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | SH2 domain-containing protein 4B. | 0.577 |
Dydc1 | Spag17 | ENSMUSP00000139412 | ENSMUSP00000134066 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.577 |
Dydc1 | Tex43 | ENSMUSP00000139412 | ENSMUSP00000038152 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Testis-expressed protein 43. | 0.685 |