| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| 9530002B09Rik | Msmb | ENSMUSP00000024032 | ENSMUSP00000022464 | RIKEN cDNA 9530002B09 gene. | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | 0.631 |
| 9530002B09Rik | Pbsn | ENSMUSP00000024032 | ENSMUSP00000000003 | RIKEN cDNA 9530002B09 gene. | Probasin. | 0.632 |
| Acpp | Klkb1 | ENSMUSP00000059889 | ENSMUSP00000026907 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | 0.665 |
| Acpp | Msmb | ENSMUSP00000059889 | ENSMUSP00000022464 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | 0.775 |
| Acpp | Nkx3-1 | ENSMUSP00000059889 | ENSMUSP00000022646 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for [...] | 0.410 |
| Acpp | Slc45a3 | ENSMUSP00000059889 | ENSMUSP00000027695 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Solute carrier family 45 member 3; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.653 |
| Acpp | Slpi | ENSMUSP00000059889 | ENSMUSP00000104992 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the innate immune response after bacterial infection. Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. R [...] | 0.592 |
| Acpp | Tgm4 | ENSMUSP00000059889 | ENSMUSP00000026893 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug. | 0.696 |
| Klkb1 | Acpp | ENSMUSP00000026907 | ENSMUSP00000059889 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | 0.665 |
| Klkb1 | Msmb | ENSMUSP00000026907 | ENSMUSP00000022464 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | 0.618 |
| Klkb1 | Nkx3-1 | ENSMUSP00000026907 | ENSMUSP00000022646 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for [...] | 0.658 |
| Klkb1 | Slc45a3 | ENSMUSP00000026907 | ENSMUSP00000027695 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | Solute carrier family 45 member 3; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.623 |
| Klkb1 | Tgm4 | ENSMUSP00000026907 | ENSMUSP00000026893 | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug. | 0.542 |
| Msmb | 9530002B09Rik | ENSMUSP00000022464 | ENSMUSP00000024032 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | RIKEN cDNA 9530002B09 gene. | 0.631 |
| Msmb | Acpp | ENSMUSP00000022464 | ENSMUSP00000059889 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family. | 0.775 |
| Msmb | Klkb1 | ENSMUSP00000022464 | ENSMUSP00000026907 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | 0.618 |
| Msmb | Nkx3-1 | ENSMUSP00000022464 | ENSMUSP00000022646 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for [...] | 0.664 |
| Msmb | Pbsn | ENSMUSP00000022464 | ENSMUSP00000000003 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Probasin. | 0.730 |
| Msmb | Sbp | ENSMUSP00000022464 | ENSMUSP00000138219 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Prostatic spermine-binding protein; This protein seems to be functional equivalent to rat prostatic spermine-binding protein, which is involved in polyamine binding. | 0.558 |
| Msmb | Slc45a3 | ENSMUSP00000022464 | ENSMUSP00000027695 | Beta-microseminoprotein; Belongs to the beta-microseminoprotein family. | Solute carrier family 45 member 3; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.542 |
