| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AI182371 | C6 | ENSMUSP00000037754 | ENSMUSP00000124417 | Expressed sequence AI182371. | Complement component 6. | 0.936 |
| AI182371 | C7 | ENSMUSP00000037754 | ENSMUSP00000106317 | Expressed sequence AI182371. | Complement component 7. | 0.929 |
| AI182371 | C8a | ENSMUSP00000037754 | ENSMUSP00000067541 | Expressed sequence AI182371. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.929 |
| AI182371 | C8b | ENSMUSP00000037754 | ENSMUSP00000031663 | Expressed sequence AI182371. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.934 |
| AI182371 | C8g | ENSMUSP00000037754 | ENSMUSP00000041855 | Expressed sequence AI182371. | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.924 |
| AI182371 | C9 | ENSMUSP00000037754 | ENSMUSP00000022749 | Expressed sequence AI182371. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. | 0.916 |
| AI182371 | Hc | ENSMUSP00000037754 | ENSMUSP00000028233 | Expressed sequence AI182371. | Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. | 0.913 |
| C4bp | C6 | ENSMUSP00000027657 | ENSMUSP00000124417 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement component 6. | 0.519 |
| C4bp | C8a | ENSMUSP00000027657 | ENSMUSP00000067541 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.664 |
| C4bp | C8b | ENSMUSP00000027657 | ENSMUSP00000031663 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.685 |
| C4bp | C8g | ENSMUSP00000027657 | ENSMUSP00000041855 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.610 |
| C4bp | C9 | ENSMUSP00000027657 | ENSMUSP00000022749 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family. | 0.824 |
| C4bp | Cd59b | ENSMUSP00000027657 | ENSMUSP00000087912 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | CD59B glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity). | 0.661 |
| C4bp | Hc | ENSMUSP00000027657 | ENSMUSP00000028233 | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. | 0.780 |
| C6 | AI182371 | ENSMUSP00000124417 | ENSMUSP00000037754 | Complement component 6. | Expressed sequence AI182371. | 0.936 |
| C6 | C4bp | ENSMUSP00000124417 | ENSMUSP00000027657 | Complement component 6. | C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. | 0.519 |
| C6 | C7 | ENSMUSP00000124417 | ENSMUSP00000106317 | Complement component 6. | Complement component 7. | 0.999 |
| C6 | C8a | ENSMUSP00000124417 | ENSMUSP00000067541 | Complement component 6. | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). | 0.991 |
| C6 | C8b | ENSMUSP00000124417 | ENSMUSP00000031663 | Complement component 6. | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.998 |
| C6 | C8g | ENSMUSP00000124417 | ENSMUSP00000041855 | Complement component 6. | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity). | 0.995 |
