| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Fcer1a | Mcpt1 | ENSMUSP00000056882 | ENSMUSP00000022836 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Mast cell protease 1; Has a chymotrypsin-like activity. | 0.600 |
| Fcer1a | Mcpt2 | ENSMUSP00000056882 | ENSMUSP00000015576 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Mast cell protease 2. | 0.455 |
| Fcer1a | Serpinb1a | ENSMUSP00000056882 | ENSMUSP00000075690 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Leukocyte elastase inhibitor A; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as [...] | 0.426 |
| Fcer1a | Serpinb2 | ENSMUSP00000056882 | ENSMUSP00000065277 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. | 0.450 |
| Fcer1a | Serpinb5 | ENSMUSP00000056882 | ENSMUSP00000108350 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). | 0.425 |
| Fcer1a | Serpinb7 | ENSMUSP00000056882 | ENSMUSP00000083896 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity); Belongs to the serpin family. Ov-serpin subfamily. | 0.425 |
| Fcer1a | Serpinb9b | ENSMUSP00000056882 | ENSMUSP00000006392 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. | 0.425 |
| Fcer1a | Serpinb9g | ENSMUSP00000056882 | ENSMUSP00000080597 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family. | 0.425 |
| Mcpt1 | Fcer1a | ENSMUSP00000022836 | ENSMUSP00000056882 | Mast cell protease 1; Has a chymotrypsin-like activity. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.600 |
| Mcpt1 | Mcpt2 | ENSMUSP00000022836 | ENSMUSP00000015576 | Mast cell protease 1; Has a chymotrypsin-like activity. | Mast cell protease 2. | 0.841 |
| Mcpt1 | Serpinb1a | ENSMUSP00000022836 | ENSMUSP00000075690 | Mast cell protease 1; Has a chymotrypsin-like activity. | Leukocyte elastase inhibitor A; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as [...] | 0.598 |
| Mcpt1 | Serpinb2 | ENSMUSP00000022836 | ENSMUSP00000065277 | Mast cell protease 1; Has a chymotrypsin-like activity. | Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. | 0.594 |
| Mcpt1 | Serpinb5 | ENSMUSP00000022836 | ENSMUSP00000108350 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). | 0.596 |
| Mcpt1 | Serpinb6b | ENSMUSP00000022836 | ENSMUSP00000105922 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family. | 0.599 |
| Mcpt1 | Serpinb7 | ENSMUSP00000022836 | ENSMUSP00000083896 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity); Belongs to the serpin family. Ov-serpin subfamily. | 0.599 |
| Mcpt1 | Serpinb9b | ENSMUSP00000022836 | ENSMUSP00000006392 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family. | 0.599 |
| Mcpt1 | Serpinb9d | ENSMUSP00000022836 | ENSMUSP00000067710 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9D; Belongs to the serpin family. | 0.599 |
| Mcpt1 | Serpinb9g | ENSMUSP00000022836 | ENSMUSP00000080597 | Mast cell protease 1; Has a chymotrypsin-like activity. | Serine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family. | 0.599 |
| Mcpt2 | Fcer1a | ENSMUSP00000015576 | ENSMUSP00000056882 | Mast cell protease 2. | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | 0.455 |
| Mcpt2 | Mcpt1 | ENSMUSP00000015576 | ENSMUSP00000022836 | Mast cell protease 2. | Mast cell protease 1; Has a chymotrypsin-like activity. | 0.841 |
