node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Col8a1 | Matn2 | ENSMUSP00000086745 | ENSMUSP00000022947 | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. | Matrilin-2; Involved in matrix assembly. | 0.523 |
Cst7 | Matn2 | ENSMUSP00000086606 | ENSMUSP00000022947 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. | Matrilin-2; Involved in matrix assembly. | 0.564 |
Dcn | Lum | ENSMUSP00000100924 | ENSMUSP00000040877 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.962 |
Dcn | Matn2 | ENSMUSP00000100924 | ENSMUSP00000022947 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Matrilin-2; Involved in matrix assembly. | 0.490 |
Dcn | Matn3 | ENSMUSP00000100924 | ENSMUSP00000020899 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. | 0.461 |
Dcn | Matn4 | ENSMUSP00000100924 | ENSMUSP00000099392 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Matrilin-4; Major component of the extracellular matrix of cartilage. | 0.429 |
Fzd6 | Matn2 | ENSMUSP00000136328 | ENSMUSP00000022947 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Matrilin-2; Involved in matrix assembly. | 0.536 |
Fzd6 | Nlk | ENSMUSP00000136328 | ENSMUSP00000119345 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] | 0.402 |
Lum | Dcn | ENSMUSP00000040877 | ENSMUSP00000100924 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.962 |
Lum | Matn2 | ENSMUSP00000040877 | ENSMUSP00000022947 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Matrilin-2; Involved in matrix assembly. | 0.700 |
Lum | Matn3 | ENSMUSP00000040877 | ENSMUSP00000020899 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. | 0.646 |
Lum | Matn4 | ENSMUSP00000040877 | ENSMUSP00000099392 | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | Matrilin-4; Major component of the extracellular matrix of cartilage. | 0.669 |
Matn2 | Col8a1 | ENSMUSP00000022947 | ENSMUSP00000086745 | Matrilin-2; Involved in matrix assembly. | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. | 0.523 |
Matn2 | Cst7 | ENSMUSP00000022947 | ENSMUSP00000086606 | Matrilin-2; Involved in matrix assembly. | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system. | 0.564 |
Matn2 | Dcn | ENSMUSP00000022947 | ENSMUSP00000100924 | Matrilin-2; Involved in matrix assembly. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.490 |
Matn2 | Fzd6 | ENSMUSP00000022947 | ENSMUSP00000136328 | Matrilin-2; Involved in matrix assembly. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.536 |
Matn2 | Lum | ENSMUSP00000022947 | ENSMUSP00000040877 | Matrilin-2; Involved in matrix assembly. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.700 |
Matn2 | Matn3 | ENSMUSP00000022947 | ENSMUSP00000020899 | Matrilin-2; Involved in matrix assembly. | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. | 0.565 |
Matn2 | Matn4 | ENSMUSP00000022947 | ENSMUSP00000099392 | Matrilin-2; Involved in matrix assembly. | Matrilin-4; Major component of the extracellular matrix of cartilage. | 0.647 |
Matn2 | Nlk | ENSMUSP00000022947 | ENSMUSP00000119345 | Matrilin-2; Involved in matrix assembly. | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] | 0.512 |