STRINGSTRING
Col2a1 protein (mouse) - STRING interaction network
"Col2a1" - Collagen alpha-1(II) chain in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Col2a1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces (1487 aa)    
Predicted Functional Partners:
Col9a3
Collagen, type IX, alpha 3 (680 aa)
   
0.961
Col9a2
Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye (688 aa)
   
0.957
Col9a1
Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye (921 aa)
   
0.956
Col8a2
Collagen alpha-2(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (699 aa)
   
0.949
Col6a1
Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family (1025 aa)
     
0.944
Adamts3
A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 (1204 aa)
     
  0.943
Sox9
Transcription factor SOX-9; Transcriptional regulator. Plays a role in chondrocyte differentiation, as part of a complex with ZNF219. Important for normal skeletal development (By similarity) (507 aa)
     
 
  0.942
Col1a2
Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family (1372 aa)
   
0.941
Col10a1
Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage (680 aa)
   
0.941
Lepre1
Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity) (748 aa)
       
  0.941
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (10%) [HD]