node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dsg3 | Flg | ENSMUSP00000064718 | ENSMUSP00000142003 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Filaggrin. | 0.468 |
Dsg3 | Krt16 | ENSMUSP00000064718 | ENSMUSP00000007280 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.462 |
Dsg3 | Krt5 | ENSMUSP00000064718 | ENSMUSP00000023709 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 5. | 0.540 |
Dsg3 | Krt6a | ENSMUSP00000064718 | ENSMUSP00000023788 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.589 |
Dsg3 | Krt6b | ENSMUSP00000064718 | ENSMUSP00000023786 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family. | 0.471 |
Flg | Dsg3 | ENSMUSP00000142003 | ENSMUSP00000064718 | Filaggrin. | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.468 |
Flg | Krt13 | ENSMUSP00000142003 | ENSMUSP00000007275 | Filaggrin. | Keratin, type I cytoskeletal 13. | 0.493 |
Flg | Krt16 | ENSMUSP00000142003 | ENSMUSP00000007280 | Filaggrin. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.735 |
Flg | Krt17 | ENSMUSP00000142003 | ENSMUSP00000079699 | Filaggrin. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] | 0.472 |
Flg | Krt5 | ENSMUSP00000142003 | ENSMUSP00000023709 | Filaggrin. | Keratin, type II cytoskeletal 5. | 0.717 |
Flg | Krt6a | ENSMUSP00000142003 | ENSMUSP00000023788 | Filaggrin. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.573 |
Flg | Krt6b | ENSMUSP00000142003 | ENSMUSP00000023786 | Filaggrin. | Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family. | 0.660 |
Flg | Sprr1b | ENSMUSP00000142003 | ENSMUSP00000058617 | Filaggrin. | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family. | 0.623 |
Flg | Sprr2d | ENSMUSP00000142003 | ENSMUSP00000039821 | Filaggrin. | Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). | 0.445 |
Krt13 | Flg | ENSMUSP00000007275 | ENSMUSP00000142003 | Keratin, type I cytoskeletal 13. | Filaggrin. | 0.493 |
Krt13 | Krt16 | ENSMUSP00000007275 | ENSMUSP00000007280 | Keratin, type I cytoskeletal 13. | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | 0.520 |
Krt13 | Krt17 | ENSMUSP00000007275 | ENSMUSP00000079699 | Keratin, type I cytoskeletal 13. | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] | 0.499 |
Krt13 | Krt5 | ENSMUSP00000007275 | ENSMUSP00000023709 | Keratin, type I cytoskeletal 13. | Keratin, type II cytoskeletal 5. | 0.494 |
Krt13 | Krt6a | ENSMUSP00000007275 | ENSMUSP00000023788 | Keratin, type I cytoskeletal 13. | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. | 0.649 |
Krt13 | Krt6b | ENSMUSP00000007275 | ENSMUSP00000023786 | Keratin, type I cytoskeletal 13. | Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family. | 0.649 |