STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Agap3Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. (910 aa)    
Predicted Functional Partners:
Tanc1
Protein TANC1; May be a scaffold component in the postsynaptic density.
   
 
 0.945
Krtap10-4
Keratin associated protein 10-4.
      
 0.604
Zfp507
Zinc finger protein 507; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
   
  
 0.575
Wdr86
WD repeat domain 86.
      
 0.528
Ttyh3
Protein tweety homolog 3; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (By similarity).
   
  
 0.520
C2cd4d
C2 calcium-dependent domain-containing protein 4D.
      
 0.502
Strn4
Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family.
   
    0.497
Lhfpl4
LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
   
  
 0.486
Zfp282
Zinc finger protein 282.
   
  
 0.465
Tanc2
Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the TANC family.
   
 
 0.450
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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