STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mrpl1439S ribosomal protein L14, mitochondrial; May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation. (145 aa)    
Predicted Functional Partners:
Mrpl36
39S ribosomal protein L36, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family.
   
 
 0.936
Mrps12
28S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family.
   
 
 0.934
Mrpl54
39S ribosomal protein L54, mitochondrial.
   
   0.933
Chchd1
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Belongs to the mitochondrion-specific ribosomal protein mS37 family.
   
   0.928
Mrpl58
Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).
   
 
 0.921
Malsu1
Mitochondrial assembly of ribosomal large subunit protein 1; Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S riboso [...]
   
 
 0.916
Mrpl20
39S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family.
   
 
 0.912
Mrps16
28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.
   
 
 0.912
Mrpl21
39S ribosomal protein L21, mitochondrial.
   
 
 0.904
Mrpl2
39S ribosomal protein L2, mitochondrial; Belongs to the universal ribosomal protein uL2 family.
   
   0.902
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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