node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ckap5 | Clip4 | ENSMUSP00000106970 | ENSMUSP00000024854 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | CAP-Gly domain-containing linker protein 4. | 0.402 |
Ckap5 | Mapre3 | ENSMUSP00000106970 | ENSMUSP00000031058 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | 0.805 |
Ckap5 | Slain2 | ENSMUSP00000106970 | ENSMUSP00000115871 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family. | 0.954 |
Clip4 | Ckap5 | ENSMUSP00000024854 | ENSMUSP00000106970 | CAP-Gly domain-containing linker protein 4. | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | 0.402 |
Clip4 | Fam71e1 | ENSMUSP00000024854 | ENSMUSP00000103560 | CAP-Gly domain-containing linker protein 4. | Protein FAM71E1. | 0.499 |
Clip4 | Map6d1 | ENSMUSP00000024854 | ENSMUSP00000043332 | CAP-Gly domain-containing linker protein 4. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.415 |
Clip4 | Mapre3 | ENSMUSP00000024854 | ENSMUSP00000031058 | CAP-Gly domain-containing linker protein 4. | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | 0.438 |
Clip4 | Mpg | ENSMUSP00000024854 | ENSMUSP00000020528 | CAP-Gly domain-containing linker protein 4. | DNA-3-methyladenine glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. | 0.588 |
Clip4 | Mrps12 | ENSMUSP00000024854 | ENSMUSP00000132443 | CAP-Gly domain-containing linker protein 4. | 28S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family. | 0.414 |
Clip4 | Nos1ap | ENSMUSP00000024854 | ENSMUSP00000125251 | CAP-Gly domain-containing linker protein 4. | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | 0.423 |
Clip4 | Rpl3l | ENSMUSP00000024854 | ENSMUSP00000129325 | CAP-Gly domain-containing linker protein 4. | Ribosomal protein L3-like; Belongs to the universal ribosomal protein uL3 family. | 0.428 |
Clip4 | Slain2 | ENSMUSP00000024854 | ENSMUSP00000115871 | CAP-Gly domain-containing linker protein 4. | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family. | 0.570 |
Fam71e1 | Clip4 | ENSMUSP00000103560 | ENSMUSP00000024854 | Protein FAM71E1. | CAP-Gly domain-containing linker protein 4. | 0.499 |
Fam71e1 | Map6d1 | ENSMUSP00000103560 | ENSMUSP00000043332 | Protein FAM71E1. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.442 |
Fam71e1 | Mrps12 | ENSMUSP00000103560 | ENSMUSP00000132443 | Protein FAM71E1. | 28S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family. | 0.441 |
Map6d1 | Clip4 | ENSMUSP00000043332 | ENSMUSP00000024854 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | CAP-Gly domain-containing linker protein 4. | 0.415 |
Map6d1 | Fam71e1 | ENSMUSP00000043332 | ENSMUSP00000103560 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | Protein FAM71E1. | 0.442 |
Mapre3 | Ckap5 | ENSMUSP00000031058 | ENSMUSP00000106970 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] | 0.805 |
Mapre3 | Clip4 | ENSMUSP00000031058 | ENSMUSP00000024854 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | CAP-Gly domain-containing linker protein 4. | 0.438 |
Mapre3 | Slain2 | ENSMUSP00000031058 | ENSMUSP00000115871 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family. | 0.539 |