STRINGSTRING
C3 protein (mouse) - STRING interaction network
"C3" - Complement C3 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C3Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa)    
Predicted Functional Partners:
Cd46
Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization (365 aa)
       
  0.993
Cfi
Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (603 aa)
     
  0.992
Cfb
Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family (763 aa)
     
  0.992
Cfd
Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (259 aa)
     
  0.992
Cfh
Complement factor H; Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway (1252 aa)
     
  0.991
Cfhr2
Complement factor H-related 2 (332 aa)
     
  0.984
C2
Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments- C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family (760 aa)
     
  0.977
Gm4788
Predicted gene 4788 (879 aa)
     
  0.976
Cfhr1
Complement factor H-related 1 (343 aa)
     
  0.975
ENSMUSG00000094924
Complement receptor 2 (347 aa)
     
  0.973
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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