STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pcdh12Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell- cell adhesion (By similarity). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton. (1180 aa)    
Predicted Functional Partners:
Cdh5
Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarit [...]
   
  
0.736
Tpbpa
Trophoblast-specific protein alpha; It may be a growth factor/hormone, perhaps involved in interaction between the maternal and fetal systems in maintenance of pregnancy.
   
  
 0.707
Prl8a8
Prolactin-8A8; Belongs to the somatotropin/prolactin family.
   
  
 0.691
Prl7b1
Prolactin-7B1.
      
 0.650
Ctsq
Cathepsin Q; Belongs to the peptidase C1 family.
      
 0.604
Prl3a1
Prolactin family 3, subfamily a, member 1.
      
 0.604
Ushbp1
Usher syndrome type-1C protein-binding protein 1.
   
  
 0.585
Gm37013
Predicted gene, 37013.
    
 
 0.571
Prl3d1
Prolactin-3D1; Belongs to the somatotropin/prolactin family.
      
 0.557
Prl7c1
Prolactin-7C1.
      
 0.544
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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